Sökning: "experimental approaches in the wild"

Visar resultat 16 - 18 av 18 avhandlingar innehållade orden experimental approaches in the wild.

1. 16. Generation and transmission of mtDNA mutations and their effect on aging

   Författare :Erik Hagström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Mutations in mtDNA are known to cause neuromuscular diseases and have been associated with several common age-associated diseases as well as being a contributor to the aging process. Despite their importance there are still important aspects of mtDNA inheritance and mtDNA mutations that remain unknown and need to be addressed. LÄS MER

3. 17. Modelling biomolecular interactions

   Författare :Johan Bredenberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Computational chemistry; molecular dynamics; nuclear receptors; force field parameterization; zinc fingers; DNA; proteins.;

   Sammanfattning : Computational approaches for understanding and aiding in molecular biology has increased in significance over the last decades, where a wealth of biochemical experiments have provided a solid ground for developing computer models that can be used to predict unresolved issues within biology. Molecular dynamics (MD) is one of these methods, based on classical laws, and suitable for handling large macromolecules in their natural environment, water. LÄS MER

4. 18. Regulation of cytotoxic lymphocyte effector functions

   Författare :Giovanna Perinetti Casoni; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Studies of patients with inborn errors of immunity provide an important opportunity to understand the human immune system in a natural context. The articles in this thesis are a compilation of such investigations. LÄS MER