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1. 1. Glutamatergic mechanisms in schizophrenia : role of endogenous kynurenic acid

   Författare :Linda K Nilsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Kynurenic acid, a tryptohan metabolite synthesised in astrocytes, is an endogenous antagonist at glutamate receptors, in particular it blocks the glycine site of the (NMDA)-receptor, and at the a7* nicotinic receptor. The compound has been found to be elevated in the cerebrospinal fluid (CSF) as well as in the postmortem prefrontal cortex of patients with schizophrenia. LÄS MER