Sökning: "the estrogen receptor α"

Visar resultat 16 - 20 av 37 avhandlingar innehållade orden the estrogen receptor α.

  1. 16. Theoretical Studies of Anti-cancer Drug Tamoxifen and Estrogen Receptor Alpha

    Författare :Gao Li; Yaoquan Tu; Lennart Nilsson; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : For decades tamoxifen (TAM) has been widely used for treatment of breast cancer by mediating mainly the estrogen receptor α (ERα) signaling pathways, whereby it suppresses estrogen stimulated cancer cell growth. The clinical response of TAM has been linked to cytochrome P450 2D6 (CYP2D6), which is the main isoform responsible for the conversion of TAM to the active metabolites 4-hydroxyTAM (OHT) and endoxifen. LÄS MER

  3. 17. Estrogen and liver X receptors in human disease

    Författare :Maria Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Estrogen Receptor; Liver X Receptor; polymorphism; Bulimia Nervosa; SNP; BMI; obesity; expression levels; T2D.;

    Sammanfattning : The nuclear hormone receptors (NRs) are a class of transcription factors that has attracted great interest due to their important roles in animal physiology and metabolism. Studies of knockout (KO) mouse models have indicated several pathophysiological conditions in which the NRs are involved. LÄS MER

  4. 18. Post-translational modification of estrogen receptor alpha and p53 in breast cancer cells

    Författare :Jian Zhu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Estrogen receptor α (ERα/ESR1) and tumor protein p53 (p53/TP53) signaling are aberrant and play important roles in breast cancer pathogenesis and evolution. ERα is highly expressed in the majority of breast cancers and is an important contributor to the development of these tumors. LÄS MER

  5. 19. Intraovarian mechanisms influencing the human corpus luteum

    Författare :Ulrika Ottander; Torbjörn Hillensjö; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Corpus luteum; steroidreceptors; progesterone; LH hCG; PGF2α; ultrasonography;

    Sammanfattning : Introduction: The human corpus luteum (CL) is a transient endocrine gland, only functionally active for about 14 days. Its principal function is to produce and secrete progesterone and thereby support the endometrium for implantation of a blastocyst and prevent rejection of the developing embryo. LÄS MER

  7. 20. Modulation of nuclear receptor signaling by RBR ubiquitin ligases

    Författare :Nina Gustafsson Sheppard; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Nuclear receptors (NRs) constitute a superfamily of transcription factors and play important roles in physiology. Transcriptional regulation by NRs can be modulated through interactions with various coregulators that activate or repress transcription through mediating receptor and chromatin modifications as well as communicating with the general transcription factor machinery. LÄS MER