Sökning: "sequence motif"

Visar resultat 1 - 5 av 124 avhandlingar innehållade orden sequence motif.

  1. 1. Decoding Heparan Sulfate

    Författare :Johan Kreuger; John T. Gallager; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Heparan sulfate; fibroblast growth factor; receptor; endostatin; angiogenesis; interaction; sequence; Biokemi; Biochemistry; Biokemi; Medical Biochemistry; medicinsk biokemi;

    Sammanfattning : Heparan sulfate (HS) is a polysaccharide of glycosaminoglycan type composed of alternating hexuronic acid [either glucuronic acid (GlcA) or iduronic acid (IdoA)] and glucosamine (GlcN) units that can be sulfated in various positions. HS binds to a large number of proteins and these interactions promote many biological processes, including cell adhesion and growth factor signaling. LÄS MER

  3. 2. Characterization of protein families, sequence patterns, and functional annotations in large data sets

    Författare :Anders Bresell; Bengt Persson; Inge Jonassen; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Bioinformatics; sequence analysis; patterns; protein families; Bioinformatics; Bioinformatik;

    Sammanfattning : Bioinformatics involves storing, analyzing and making predictions on massive amounts of protein and nucleotide sequence data. The thesis consists of six papers and is focused on proteins. LÄS MER

  4. 3. The MHC-glycopeptide-T cell interaction in collagen induced arthritis : a study using glycopeptides, isosteres and statistical molecular design in a mouse model for rheumatoid arthritis

    Författare :Lotta Holm; Jan Kihlberg; Morten Grötli; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Rheumatoid arthritis; collagen; T-cell; class II MHC; solid phase peptide synthesis; glycopeptide; peptide isostere; PCA; statistical molecular design; PLS; QSAR; sequence binding motif; Organic chemistry; Organisk kemi;

    Sammanfattning : Rheumatoid arthritis (RA) is an autoimmune disease affecting approximately 1% of the population in the western world. It is characterised by a tissue specific attack of cartilage in peripheral joints. Collagen induced arthritis (CIA) is one of the most commonly used animal models for (RA), with similar symptoms and histopathology. LÄS MER

  5. 4. Folding of the Ribosomal protein S6 : The role of sequence connectivity, overlapping foldons, and parallel pathways

    Författare :Ellinor Haglund; Mikael Oliveberg; Neil Ferguson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein folding; protein stability; two-state folding; S6; chevron plot; transition state; parallell pathways; foldon; two-channel landscape; protein engineering; H D-exchange; Biochemistry; Biokemi; Biochemistry; biokemi;

    Sammanfattning : To investigate how protein folding is affected by sequence connectivity five topological variants of the ribosomal protein S6 were constructed through circular permutation.  In these constructs, the chain connectivity (i.e. the order of secondary-structure elements) is changed without changing the native-state topology. LÄS MER

  7. 5. Evolution and viral mimicry of short linear motif-mediated interactions

    Författare :Filip Mihalič; Per Jemth; Leo James; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; phage display; protein-protein interactions; large-scale discovery; short linear motifs; viral mimcry; viral hijacking; Biokemi; Biochemistry; Medical Biochemistry; Medicinsk biokemi;

    Sammanfattning : Proteins are one of the most fundamental building blocks of life and their interactions regulate every cellular process. Historically they have been conceptualized as predominantly folded entities with well-defined secondary and tertiary structures. LÄS MER