Sökning: "sequence alignment"

Visar resultat 21 - 25 av 57 avhandlingar innehållade orden sequence alignment.

1. 21. Integrated Optical Slot-Waveguide Ring Resonator Sensor Arrays for Lab-on-Chip Applications

   Författare :Kristinn Björgvin Gylfason; Göran Stemme; Hans Sohlström; Peter Bienstman; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; biosensor; label-free biosensing; ring resonator; optical waveguide; lab-on-a-chip; Electronic measurement and instrumentation; Elektronisk mät- och apparatteknik; Photonics; Fotonik;

   Sammanfattning : This thesis treats the development of an integrated optical sensor array. The sensors are slot-waveguide ring resonators, integrated with on-chip surface grating couplers and light splitters, for alignment tolerant, real-time, refractive index sensing, and label-free biosensing. LÄS MER

3. 22. Dimension Reduction and Signal Decomposition for Genotype–Phenotype Relations

   Författare :Rasmus Perby Henningsson; Matematik LTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Matematik; Bioinformatik; Dimensionsreduktion; Computational mathematics; Bioinformatics; Dimension reduction;

   Sammanfattning : Over the last few decades, DNA sequencing has developed from costing billions of dollars to get the complete sequence of the human genome, to being a routine procedure performed in labs all around the world. This has transformed the field of experimental biology since measurements can be done at a level of detail that was not possible before. LÄS MER

4. 23. Structural Insights into the Acquisition and Storage of Iron

   Författare :Ulrika Schagerlöf; Biokemi och Strukturbiologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Strukturkemi; Molecular biophysics; Molekylär biofysik; Structure chemistry; single particle; ferric reductase; human phagocyte superoxide-generating NADPH oxidase; frataxin; cryo electron microscopy; FRO2; iron homeostasis; iron acquisition;

   Sammanfattning : It is of vital importance to understand the systems for iron metabolism and this thesis contributes to this by providing insights into the structure and function of the acquisition and homeostasis of iron. The two proteins that have been primarily investigated are a ferric reductase from Arabidopsis thaliana called FRO2 and a mitochondrial iron chaperone from Saccharomyces cerevisiae called frataxin. LÄS MER

5. 24. Structure-function studies of epoxide hydrolases

   Författare :Agata Naworyta; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : Epoxides are three-membered cyclic ethers formed in cells via several metabolic pathways. Epoxide hydrolases (EHs) are enzymes that hydrolyse epoxides to the corresponding diols. The main goal of this thesis was to investigate the structures of EHs from the alpha/beta-hydrolase family. LÄS MER

7. 25. The immunoglobulin heavy chain 3ʼ enhancer : coupling of basic-Helix-Loop-Helix proteins to the regulation of enhancer function

   Författare :Velmurugesan Arulampalam; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : During B lymphocyte development, the transcriptional activity of the IgH locus is subject to spatial and temporal changes. One cis-control element, the IgH 3' enhancer, has been implicated in regulating functional events in late B cell development. LÄS MER