Sökning: "selenoproteins"

Visar resultat 6 - 10 av 13 avhandlingar innehållade ordet selenoproteins.

  1. 6. Stretching the genetic code : incorporation of selenocysteine at specific UGA codons in recombinant proteins produced in Escherichia coli

    Författare :Olle Rengby; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Selenocysteine (Sec) exists in all domains of life and represents the 21st naturally occurring amino acid. A Sec residue is co-translationally incorporated at a predefined opal (UGA) codon. UGA codons normally encode for translational stop via the protein release factor 2 (RF2). LÄS MER

  3. 7. Development of a Sel-tag for multimodality imaging and studies of mammalian thioredoxin reductase 1

    Författare :Qing Cheng; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Selenocysteine (Sec; U in one-letter code), the 21st amino acid existing in all selenoproteins, has unique biochemical properties due to its selenium atom, including a low pKa and a high reactivity with many electrophilic agents. When a selenoprotein is translated, the insertion of Sec occurs at a UGA codon, normally yielding translational termination. LÄS MER

  4. 8. Cytotoxic mechanisms of selenium in cancer

    Författare :Eric Olm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Selenium is an essential trace element with a diverse number of functions in the body as part of multiple selenoproteins. Acknowledged for its cancer preventive properties in clinical trials, selenium has in recent years also evolved as a potential chemotherapeutic agent. LÄS MER

  5. 9. Recessive parkinsonism, mitochondria and translational regulation

    Författare :Jeff Blackinton; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Three genes are known to cause recessive forms of Parkinson disease (PD) in humans: parkin, PINK1 and DJ-1. Of these, the rarest is DJ-1; less than fifty known cases worldwide are due to mutations in DJ-1. LÄS MER

  7. 10. Selenium Compounds and Antioxidant Capacity in Bovine Milk. Studies on Glutathione Peroxidase, Bioavailability and Electrochemical Techniques

    Författare :Jun Chen; Kemiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; General biomedical sciences; Biomedicinska vetenskaper allmänt ; Kemiteknik och kemisk teknologi; Chemical technology and engineering; Livsmedelsteknik; Food and drink technology; amperometry; voltammetry; antioxidant capacity; ileostomy; bioavailability; glutathione peroxidase; bovine milk; selenium;

    Sammanfattning : The efficacy and function of antioxidants have been intensively studied in foods and other biological systems in recent decades. This thesis concerns different aspects of the antioxidant properties of bovine milk, with emphasis on measurement of the total antioxidant capacity (TAC), the activity of the selenium-containing glutathione peroxidase (GSHPx), and the bioavailability of selenium from bovine milk in humans. LÄS MER