Sökning: "proteasome inhibition"

Visar resultat 11 - 15 av 57 avhandlingar innehållade orden proteasome inhibition.

  1. 11. Proteasome inhibition in the regulation of natural killer cell function and multiple myeloma cell apoptosis

    Författare :Xiaoli Feng; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Multiple myeloma (MM) is a hematologic malignancy mostly occurring in the elderly and characterized by an expansion of monoclonal plasma cells in the bone marrow and increased monoclonal immunoglobulin in plasma. The outcome of this disease has been greatly improved due to introduction of new drugs. LÄS MER

  3. 12. Identification and characterization of a proteasome deubiquitinase inhibitor

    Författare :Slavica Brnjic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The 26S proteasome has emerged as an attractive therapeutic target in the treatment of cancers. Proteasome inhibitors have been shown to selectively kill cancer cells. The FDA approval of bortezomib for the treatment of multiple myeloma and mantle cell lymphoma has clinically validated the 26S proteasome as a therapeutic target in oncology. LÄS MER

  4. 13. Functional studies of the ubiquitin proteasome system using GFP based reporters

    Författare :Kristina Lindsten; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Ubiquitin; proteasome; green fluorescent protein GFP ; degradation; inhibitor; Gly-Ala repeat; neurodegencration; poly-Gln aggregates.;

    Sammanfattning : Ubiquitin-dependent proteasomal degradation is of paramount importance for cellular processes such as cell cycle progression, transcriptional regulation, apoptosis and disposal of misfolded and aberrant proteins. Moreover the ubiquitin-proteasome system is the main producer of peptides used by major histocompatibility complex class 1 for antigen presentation. LÄS MER

  5. 14. Pancreatic Cancer. Experimental and Clinical Studies

    Författare :David Ljungman; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pancreatic neoplasms; Proteasome inhibitors; Apoptosis; Intracellular signaling peptides and proteins; Epidermal growth factor receptor; Pancreaticoduodenectomy; Cost and cost analysis; Quality-adjusted life years; Copy number variations; Comparative genomic hybridization;

    Sammanfattning : Background: Pancreatic cancer is one of the most lethal of known cancers and the only treatment with possibility of cure is surgery. The costs associated with treatment of pancreatic cancer are reputably high, both in terms of morbidity and financially. LÄS MER

  7. 15. Proteasome Inhibitors against Cancer: Determining Biology and Finding Novel Compounds

    Författare :Arjan Mofers; Stig Linder; Padraig D´arcy; Sonia Lain; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Cancer continues to be a tremendous burden on society in terms of loss of quality of life and life-years. The ubiquitin proteasome system (UPS), responsible for the bulk of protein turnover in the cell, is considered an attractive target in cancer therapy. LÄS MER