Sökning: "pigment epithelium derived factor"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden pigment epithelium derived factor.

  1. 1. Targeting the prostate tumor microenvironment and vasculature : the role of castration, tumor-associated macrophages and pigment epithelium-derived factor

    Författare :Sofia Halin; Anders Bergh; Pernilla Wikström; Stina Rudolfsson; Carl-Henrik Heldin; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; angiogenesis; castration therapy; microenvironment; stroma; tumor-associated macrophages; pigment epithelium-derived factor; PEDF; vasculature; Pathology; Patologi; patologi; Pathology;

    Sammanfattning : BACKGROUND: Prostate cancer is the most common cancer among Swedish men. For patients with metastatic prostate cancer the standard therapy is castration, a treatment that initially provides symptomatic relief but unfortunately is not curative. New therapeutic targets for advanced prostate cancer are therefore needed. LÄS MER

  3. 2. Regulation of Hematopoietic Stem Cells

    Författare :Emma Rörby; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoiesis; hematopoietic stem cells; hematopoietic stem cell expansion; cord blood; transforming growth factor beta; Smad signaling; pigment epithelium derived factor; CD9;

    Sammanfattning : This thesis is about the regulation of hematopoietic stem cells (HSCs) that represent rare cells residing in the bone marrow (BM) of adults. They are multipotent cells that have the capacity to differentiate to all mature cells of the blood system and have the capacity to self-renew, i.e. generate new HSCs. LÄS MER

  4. 3. Stem cell function and organ development : analysis of Lhx2 function in hematopoietic stem cells and eye development

    Författare :Lina Dahl; Leif Carlsson; Jan-Ingvar Jönsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lhx2; hematopoietic system; hematopoietic stem cell; progenitor; embryonic stem cell; embryoid body; eye development; forebrain; eye field transcription factor; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; molekylär medicin genetik och patologi ; molecular medicine  genetics and pathology ;

    Sammanfattning : When a multicellular organism suffers damages to tissues/organs it heals itself by either substituting the lost cellular matrix by scar formation or by regenerating the lost tissue. Regeneration likely occurs by a recapitulation of the developmental process that formed the organ. LÄS MER

  5. 4. Inner ear proteomics and barriers : Clinical and experimental findings

    Författare :Jesper Edvardsson Rasmussen; Göran Laurell; Per Olof Eriksson; Helge Rask-Andersen; Jonas Bergquist; Måns Magnusson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vestibular schwannoma; Hearing loss; Inner ear; Proteome; Perilymph; Endolymph; Furosemide; NKCC1; Fetuin-A; Complement component factor-H realted protein 2; CFHR2; Inflammation; MRI; Oto-Rhino-Laryngology; Oto-rhino-laryngologi; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Hearing is important in many aspects of life, including communication, assessing one’s surroundings, entertainment and social interaction. Hearing loss is common and according to the Global Burden of Disease Study, 5% of the global population require hearing rehabilitation (1). LÄS MER

  7. 5. Investigating mechanisms of angiogenesis in health and disease using zebrafish models

    Författare :Zaheer Ali; Lasse D. Jensen; Neil Lagali; Massimo Santoro; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Angiogenesis, the growth of blood vessels from an existing vasculature, can occur by sprouting from preexisting vessels or by vessel splitting (intussusception). Pathological angiogenesis drives choroidal neovascularization (CNV) in age related macular degeneration (AMD) which is commonly restricted under the retinal pigment epithelium (RPE), called occult CNV, but may also involve vessels penetrating through the RPE into the sub-retinal space. LÄS MER