Sökning: "CD9"

Visar resultat 1 - 5 av 12 avhandlingar innehållade ordet CD9.

  1. 1. Regulation of Hematopoietic Stem Cells

    Författare :Emma Rörby; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoiesis; hematopoietic stem cells; hematopoietic stem cell expansion; cord blood; transforming growth factor beta; Smad signaling; pigment epithelium derived factor; CD9;

    Sammanfattning : This thesis is about the regulation of hematopoietic stem cells (HSCs) that represent rare cells residing in the bone marrow (BM) of adults. They are multipotent cells that have the capacity to differentiate to all mature cells of the blood system and have the capacity to self-renew, i.e. generate new HSCs. LÄS MER

  3. 2. Early fate decisions in hematopoietic stem and progenitor cells. Through the lens of genomic and functional assays

    Författare :Fatemeh Safi; Avdelningen för molekylär hematologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoiesis; HSCs; singel cell sc ; scRNA-seq; scATAC-seq; CD9; Aging;

    Sammanfattning : Hematopoietic stem cells (HSCs) are rare cells on top of the differentiation hierarchy of hematopoiesis. HSCs are unique in their combined capacity to differentiate into all mature blood lineages and self-renew to maintain the HSC pool. LÄS MER

  4. 3. Cell biological mechanisms and activity markers of eosinophils in relation to allergic inflammation

    Författare :Eva C Fernvik; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :allergic inflammation; CD9; CD11b; EG2; eosinophils; flow cytometry; FOG-method;

    Sammanfattning : It is becoming increasingly apparent that the pathogenesis of respiratory allergic diseases, including asthma and allergic rhinitis, is closely linked to the presence of chronic inflammation. One of the leading actresses in the allergic inflammatory process is the eosinophil granulocyte. LÄS MER

  5. 4. Molecular dissection of B-lymphocyte signalling using expression profiling

    Författare :Jessica M Lindvall; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Btk; B-lymphocyte; gene expression profiling; signal transduction;

    Sammanfattning : Gene expression profiling and bioinformatics have emerged into playing a large and diverse role in many aspects of both the clinical and molecular research. These two approaches have in this thesis work been used in combination in order to shed light to the role of Bruton's tyrosine kinase (Btk) in B-lymphocyte development and signal transduction. LÄS MER

  7. 5. Mechanisms Underlying the Specification of Definitive Hematopoiesis

    Författare :Rita Alves; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GATA2; mitotic bookmarking; HSC; transcription factors; reprogramming;

    Sammanfattning : Hematopoietic stem cells (HSCs) maintain blood through self-renewal and differentiation. Although HSC transplantation is the only cure for various blood disorders, generating and maintaining HSCs in vitro remains challenging, partly due to a limited understanding of the cellular and molecular mechanisms underlying human HSC ontogeny. LÄS MER