Sökning: "phoP"

Hittade 2 avhandlingar innehållade ordet phoP.

  1. 1. Mechanisms and Biological Costs of Bacterial Resistance to Antimicrobial Peptides

    Författare :Hava Lofton Tomenius; Dan I Andersson; Ørjan Samuelsen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antimicrobial peptides; antibiotic resistance; fitness cost; Salmonella Typhimurium; Staphylococcus aureus; bile; serum; pH response; growth rate; mice; phoP; pmrB; waaY; LPS; LL-37; defensins; membrane potential; Mikrobiologi; Microbiology;

    Sammanfattning : The global increasing problem of antibiotic resistance necessarily drives the pursuit and discovery of new antimicrobial agents. Antimicrobial peptides (AMPs) initially seemed like promising new drug candidates. Already members of the innate immune system, it was assumed that they would be bioactive and non-toxic. LÄS MER

  3. 2. The effects of internally expressed Contact-Dependent growth Inhibition (CDI) toxins in bacteria

    Författare :Magnus Stårsta; Sanna Koskiniemi; Pierre Genevaux; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Bacteria, both pathogenic and non-pathogenic, have developed multiple forms of competition mechanisms to combat each other including, but not limited to, Contact-Dependent growth Inhibition (CDI) systems, Type VI Secretion Systems and the associated Rearrangement hotspot (Rhs) toxin system. These systems usually confers a great fitness advantage as they allow for precise delivery of toxic molecules into competing bacteria whilst sister cells are protected from auto-inhibition by producing a cognate immunity protein. LÄS MER