Sökning: "pancreatic alpha cells"

Visar resultat 21 - 25 av 35 avhandlingar innehållade orden pancreatic alpha cells.

1. 21. Roles of unconventional ion channels and insulin granule structure in the pathogenesis of type-2 diabetes

   Författare :Mohammad Barghouth; Diabetes - öpatofysiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; T2D; pancreatic islets; mechanosensitive channels; Piezo1; beta-cell specific Piezo1 knockout mouse; KATP channel; dSTORM; Piezo1; Cav3.2; AQP1; SD; RRP; Insulin secretion and action;

   Sammanfattning : T2D is the most widespread endocrine disease. In conventional stimulus secretion coupling increased blood glucose is metabolized causing an increased intracellular level of ATP and closure of the KATP channels, and this, in turn, depolarizes the cell membrane leading to the opening of voltage-gated Ca2+ channels, the influx of Ca2+ and exocytosis of insulin granules. LÄS MER

3. 22. Studies on proteins involved in the molecular regulation of insulin exocytosis

   Författare :Wei Zhang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Actin; ADP; ATP; Ca2 channel; CAPS; beta-cells; CSP; exocytosis; GK rat; insulin; islet; Mint; Munc-18; NSF; PI 4-kinase; PI 4 P; PI 4; 5 P2; alpha-SNAP; SNAP-25; synaptotagmin III; syntaxin; tomosyn; type 2 diabetes mellitus; VAMP-2.;

   Sammanfattning : Type 2 diabetes mellitus is a disease characterized by impaired insulin secretion and insulin resistance. Better understanding of molecular mechanisms of insulin secretion may help to optimize type 2 diabetes management. LÄS MER

4. 23. The Free Fatty Acid Receptor GPR40 - expression and role in islet hormone secretion

   Författare :Erik Flodgren; Lund Medicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetology; secreting systems; Endocrinology; GPCR; Glucagon; GPR40; Insulin; Free fatty acid; Endokrinologi; sekretion; diabetologi;

   Sammanfattning : Type 2 diabetes (T2D) is a serious condition of growing proportions. Developing via an increasing imbalance between insulin sensitivity in the peripheral tissues and insulin release from pancreatic beta-cells, it ultimately renders the individual incapable of regulating the blood glucose concentration, e.g. after a meal. LÄS MER

5. 24. Murine insulin-dependent diabetes mellitus : a model for disease development and protection

   Författare :Björn Pilström; Dan Holmberg; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; Immunologi; immunologi; Immunology;

   Sammanfattning : Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease caused by destruction of the insulin-producing beta cells in the pancreatic Langerhans' islets. This destruction is preceded by an infiltration of mononuclear leukocytes called insulitis. LÄS MER

7. 25. Art of tumor immunity : extricating hypoxia-driven immunosuppression in the solid tumor microenvironment

   Författare :Apple Tay; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The fate of tumors, from initiation to in situ carcinoma and ultimately metastasis, is intricately tied to the balance between the immune system’s effector cytotoxic and tolerogenic immunosuppressive responses, collectively known as tumor immunity. However, this balance is disrupted by hypoxia, a common characteristic of solid tumors, which drives immunosuppression and contributes to the heterogeneity of the solid tumor microenvironment (TME). LÄS MER