Sökning: "pH-dependent solubility"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden pH-dependent solubility.

1. 1. Computational and Experimental Models for the Prediction of Intestinal Drug Solubility and Absorption

   Författare :Christel A. S. Bergström; Per Artursson; Han van de Waterbeemd; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; aqueous drug solubility; melting point; intestinal drug permeability; pH-dependent solubility; multivariate data analysis; molecular descriptors; molecular surface area; in silico modeling; drug absorption; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

   Sammanfattning : New effective experimental techniques in medicinal chemistry and pharmacology have resulted in a vast increase in the number of pharmacologically interesting compounds. However, the number of new drugs undergoing clinical trial has not augmented at the same pace, which in part has been attributed to poor absorption of the compounds. LÄS MER

3. 2. Pharmaceutical cocrystals : formation mechanisms, solubility behaviour and solid-state properties

   Författare :Amjad Alhalaweh; Peter York; Luleå tekniska universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; crystal engineering; cocrystal; formation; solubility; pH; dissolution; surface properties; solid-state properties; Health Science; Hälsovetenskap;

   Sammanfattning : The primary aim of pharmaceutical materials engineering is the successful formulation and process development of pharmaceutical products. The diversity of solid forms available offers attractive opportunities for tailoring material properties. LÄS MER

4. 3. A star is born : development of NT* as a new biotechnological tool based on the mechanism of pH dependent dimerization of the spidroin N-terminal domain

   Författare :Médoune Sarr; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Proteins are widely used in research and in the pharmaceutical industry but the production of recombinant protein can be tedious, costly and time-consuming due to unwanted aggregation. Strategies to circumvent aggregation, e.g. the use of solubility tags, must be evaluated experimentally and successful results are not always obtained. LÄS MER

5. 4. Molecular mechanisms of amyloid self-regulation

   Författare :Michael Landreh; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Amyloid is associated with both pathological protein deposits and the formation of functional protein structures. Therefore, several strategies have evolved to control the formation or inhibition of amyloid in vivo. LÄS MER

7. 5. Targeting Mycobacterium tuberculosis Proteins: Structure and Function Studies of Five Essential Proteins

   Författare :Adrian Suarez Covarrubias; Sherry Mowbray; Torsten Unge; Pedro Alzari; Uppsala universitet; []
   Nyckelord :Cell and molecular biology; carbonic anhydrase; threonine synthase; FAS II; Rv0636; Rv1284; Rv1295; Rv3588c; Rv3778c; X-ray crystallography; Cell- och molekylärbiologi; Mycobacterium tuberculosis;

   Sammanfattning : This thesis describes the target selection, cloning, expression, purification, crystallization, structure and biochemical characterization of five essential Mycobacterium tuberculosis (Mtb) proteins. The search for drugs against the causal agent of tuberculosis is urgently needed and the targeting of essential genes is necessary to fulfill this goal. LÄS MER