Sökning: "myosin IC"

Hittade 4 avhandlingar innehållade orden myosin IC.

1. 1. Cellular, Molecular and Functional Characterization of the Tumor Suppressor Candidate MYO1C

   Författare :Kittichate Visuttijai; Afrouz Behboudi; Katarina Ejeskär; Anders Oldfors; Volker Haucke; Högskolan i Skövde; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MYO1C; myosin IC; tumor suppressor gene; cancer; tumor; PI3K AKT signaling; Medical sciences; Medicin; MYO1C; myosin IC; tumor suppressor gene; cancer; tumor; PI3K AKT signaling;

   Sammanfattning : Tumor suppressor genes play a role as a growth regulator and a gatekeeper of a cell. Their inactivation is often detected in malignant tumors. Identification of novel tumor suppressor gene candidates may help to further understand tumorigenesis and aid in the discovery of a new treatment leading toward cure of cancer. LÄS MER

3. 2. Outcomes of Myosin 1C Gene Expression Depletion on Cancer-related Pathways, in Vitro and in Clinical Samples

   Författare :Anna Pfister; Afrouz Behboudi; Sahlgrenska Academy at University of Gothenburg; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MYO1C; myosin 1C; gene expression; pathway analysis; endometrial carcinoma;

   Sammanfattning : The unconventional myosin IC has previously been suggested to be a haploinsufficient tumour suppressor. The mechanism for this action has hitherto been unknown, however, and hence we decided to attempt to elucidate the genes involved. LÄS MER

4. 3. Effects of ageing on contractility and myosin composition of rat and man skeletal muscles and muscle cells : with special reference to muscle adaptability

   Författare :Xiaopeng Li; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :ageing; hyperthyroidism; skeletal muscle; single skinned fibre; isometric twitch; slack test; shortening velociy; electrophoresis; myosin isoform; immunocytochemistry;

   Sammanfattning : The aims of this thesis were to characterize the effects of ageing on the contractile and biochemical properties of fast- and slow-twitch skeletal muscles at the whole muscle and single fibre level in an attempt to improve our understanding of the mechanisms underlying the age-related impairments of muscle fibres. Specific interest was in the adaptability of skeletal muscle and the regulation of speed of shortening at single-cell level in the rat and man. LÄS MER

5. 4. Adaptability of skeletal muscle to hormone treatment in relation to gender and aging

   Författare :Fushun Yu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :skinned muscle fiber; gender; aging; steroid hormone; V0 electrophoresis; MyHC; MyLC; enzymehistochemistry; hyperthyroid rat; thyroid hormone receptor TR deficient TR[alpha]1 - -; TR[beta]- -; and TR[alpha]1- -[beta]- - mice;

   Sammanfattning : The aims of this study were to investigate the expression of myosin isoforms, muscle contractility at the cell level, and changes in these parameters in response to altered hormonal status in aging male and female rodents. In addition, by using mice lacking thyroid hormone receptors (TR[alpha]1 or TR[beta] or TR[alpha]1/[beta]) we tried to improve our understanding of the mechanisms by which thyroid hormone regulates the expression of specific MyHC isoforms via these different nuclear receptors. LÄS MER