Sökning: "metalloenzyme"

Visar resultat 1 - 5 av 12 avhandlingar innehållade ordet metalloenzyme.

  1. 1. Characterization of two novel fatty acid dioxygenases : Linoleate diol synthase and manganese lipoxygenase

    Författare :Chao Su; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Dioxygenase; hemeprotein; lipoxygenase; metalloenzyme; oxylipin; fatty acid; manganese-protein; Gaeumannomyces graminis; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; galenisk farmaci; Pharmaceutics;

    Sammanfattning : Two classes of fatty acid dioxygenases, PGH synthases (hemeproteins) and lipoxygenases (non-heme iron proteins), are of eminent pharmacological importance. This thesis describes a PGH synthase-related dioxygenase designated linoleate diol synthase (LDS) and the first native occurring manganese-containing lipoxygenase. LÄS MER

  3. 2. Asymmetric transformation of ß- and γ-functionalized alcohols : Study of combined ruthenium-catalyzed racemization and enzymatic resolution

    Författare :Annika Träff; Jan-Erling Bäckvall; Reko Leino; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Kinetic resolution; dynamic kinetic resolution; kinetic asymmetric transformation; dynamic kinetic asymmetric transformation; enzyme catalysis; racemization; asymmetric synthesis; chlorohydrin; cyano acetate; amino alcohol; metalloenzyme; bifunctional catalytic system; Organic synthesis; Organisk syntes; organisk kemi; Organic Chemistry;

    Sammanfattning : The major part of this thesis describes the asymmetric synthesis of β- and γ-amino alcohols through the combination of ruthenium catalyzed racemization and enzymatic kinetic resolution. The dynamic kinetic resolution, DKR, protocol for chlorohydrins was improved by employing Bäckvall’s catalyst, which is a base activated racemization catalyst, in combination with Burkholderia cepacia lipase. LÄS MER

  4. 3. Outer Coordination Spheres Engineering of Ru-based Molecular Water Oxidation Catalysts

    Författare :Tianqi Liu; Licheng Sun; Julio Lloret-Fillol; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; solar fuels; water oxidation; catalysis; ruthenium complex; Ru-bda; Ru-pda; outer coordination sphere; hydrophobic interactions; Kemi; Chemistry;

    Sammanfattning : The outer coordination sphere plays a vital role in metalloenzyme catalysis, while this principle is relatively less considered in the design of man-made molecular catalysts. This thesis investigates the role of outer coordination spheres in water oxidation by a series of ruthenium-based complexes. LÄS MER

  5. 4. Evolution and structure of leukotriene A4 hydrolase

    Författare :Filippa Kull; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Leukotriene (LT) B4 is a potent leukocyte chemotactic and aggregating agent involved in a variety of inflammatory and allergic disorders. The enzyme leukotriene A4 hydrolase catalyzes the hydrolysis of LTA4 into this proinflammatory mediator, leukotriene B4. LÄS MER

  7. 5. Push the limitations of crystal structure determination by 3D electron diffraction : From inorganic porous materials to biomolecules

    Författare :Jingjing Zhao; Xiaodong Zou; Hongyi Xu; Tim Grüne; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; electron crystallography; 3D electron diffraction; cryo-EM specimen preparation; structure determination; porous materials; biomolecules; fysikalisk kemi; Physical Chemistry;

    Sammanfattning : Structure elucidation is fundamental to understanding the chemical and physical properties of a material. Three-dimensional electron diffraction (3D ED) has shown great power for structure determination of nanometer- or submicrometer-sized crystals that are either too small or too complex for X-ray diffraction. LÄS MER