Sökning: "melanocortin"

Visar resultat 11 - 15 av 30 avhandlingar innehållade ordet melanocortin.

  1. 11. The Role of the Melanocortin System in Linking Energy Homeostasis with Reward Mechanisms

    Författare :Jonas Lindblom; Per Södersten; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; farmaceutisk farmakologi; Pharmaceutical Pharmacology;

    Sammanfattning : There is evidence of a link between peripheral signals of energy homeostasis and reward mechanisms. A hypothesis was formulated that the melanocortin (MC) system is part of this link. The hypothesis was tested by a series of receptor expression and neurochemical studies in rats. LÄS MER

  3. 12. Evolution of Membrane Bound Proteins and their Ligands : The Melanocortin (MC) Receptor Inverse Agonists AgRP2, ASIP2, Drug/Metabolite Transporters, and SPNS1

    Författare :Åke Västermark; Helgi Schiöth; Arne Elofsson; Uppsala universitet; []
    Nyckelord :;

    Sammanfattning : Integral membrane proteins play a key role hormonal and neuronal signaling. Transmembrane helix (TM) proteins form about 27% of the human proteome. Furthermore, 44% of the human drug targets are receptors, and 19% of these are seven-transmembrane domain receptors (GPCRs), which constitute 4% of the entire protein-coding genome. LÄS MER

  4. 13. Localization and expression of melanocortin receptors in melanoma cells, adrenal gland and brain

    Författare :Yun Xia; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Sammanfattning : .... LÄS MER

  5. 14. Discovery of novel selective ligands, expression and structural characterisation of the melanocortin receptor subtypes

    Författare :Helgi B. Schiöth; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Sammanfattning : .... LÄS MER

  7. 15. Expression and purification of membrane proteins: Focus on the G-protein coupled receptor MC4r

    Författare :Viveka Dolby; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; enzymology; Proteiner; enzymologi; Proteins; melanocortin 4 receptor; GPCR; purification; Expression; membrane proteins;

    Sammanfattning : Membrane proteins are crucial components of the cell and are involved in many biological processes. Recombinant overexpression systems together with different purification methods are necessary to obtain large amounts of purified receptor for biophysical and functional studies. LÄS MER