Sökning: "medicin 2012"

Visar resultat 1 - 5 av 710 avhandlingar innehållade orden medicin 2012.

  1. 1. Cardiac hypertrophy : transcription patterns, hypertrophic progression and extracellular signalling

    Författare :Nina Gennebäck; Stellan Mörner; Anders Waldenström; Urban Hellman; Ali J Marian; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiac hypertrophy; HCM; gene expression; OPLS-DA; multivariate dataanalysis; cardiomyocytes; exosomes; microvesicles; Medicine; medicin;

    Sammanfattning : Background: The aim of this thesis was to study transcription patterns and extracellular signalling of the hypertrophic heart to better understand the mechanisms initiating, controlling and maintaining cardiac hypertrophy.Cardiac hypertrophy is a risk factor for cardiovascular morbidity and mortality. LÄS MER

  3. 2. Gene Expression and DNA Methylation in Acute Lymphoblastic Leukemia

    Författare :Jessica Nordlund; Syvänen Ann-Christine; Xavier Estivill; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Digital gene expression; Allele-specific gene expression; DNA methylation; Epigenetics; Acute lymphoblastic leukemia; Molekylär medicin; Molecular Medicine;

    Sammanfattning : Pediatric acute lymphoblastic leukemia (ALL) is the most common malignancy in children, which results from the malignant transformation of progenitor cells in the bone marrow into leukemic cells. The precise mechanisms for this transformation are not well defined, however recent studies suggest that aberrant regulation of gene expression or DNA methylation may play an important role. LÄS MER

  4. 3. Global Assessment of Attention Deficit Hyperactivity Disorder : Examining Objective Measures of Hyperactivity, Impulsivity and Inattention in Adults

    Författare :Hanna Edebol; Torsten Norlander; Lars Helldin; Leif Lindström; Philip Asherson; Karlstads universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Attention Deficit Hyperactivity Disorder; Objective measures; Adults; Psychometrics; Diagnosis; Treatment; Psykologi; Psychology; Psychology;

    Sammanfattning : The aim of this thesis is to examine objective laboratory measures of Attention Deficit Hyperactivity Disorder (ADHD) in adult persons and to develop measures for diagnosis and treatment using a psychometric instrument called the Quantified Behavior Test Plus. The instrument objectively quantifies cardinal symptom manifestations in adult ADHD using motion tracking devices and continuous performance testing. LÄS MER

  5. 4. Obesity-associated inflammation in adipose tissue

    Författare :Malin Alvehus; Tommy Olsson; Agneta Holmäng; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adipose tissue; inflammation; pro-inflammatory cytokines; serum; obesity; weight loss; menopause;

    Sammanfattning : Background: Excess body fat, particularly in the visceral depot, is linked to increased mortality and morbidity, including the development of diseases such as type 2 diabetes, cardiovascular disease, and cancer. Chronic low-grade inflammation in adipose tissue may be a key mediator of obesity-associated diseases. LÄS MER

  7. 5. Left atrial function in health and disease

    Författare :Mark Henein; Per Lindqvist; Stellan Mörner; Reidar Winter; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Left atrium; Doppler echocardiography; atrial interaction; atrial pressure;

    Sammanfattning : The Objectives of this thesis are:1) To study possible atrial interaction in patients with right and left ventricular outflow tract obstruction due to significant pulmonary (PS) and aortic valve stenosis (AS), respectively.2) To assess left atrial (LA) intrinsic myocardial function and its relationship to indirect measures of left ventricular (LV) filling pressures in patients with paroxysmal atrial fibrillation (PAF). LÄS MER