Sökning: "insulitis"
Visar resultat 11 - 14 av 14 avhandlingar innehållade ordet insulitis.
11. Antigen presenting cells in autoimmune diabetes: phenotype, function and modulation by Linomide
Sammanfattning : The aim of this thesis was to better understand the role of antigen presenting cells (APC) in the development of diabetes in the nonobese diabetic (NOD) mouse. We have shown that DC and Mphi that infiltrate the islets of Langerhans produce tumour necrosis factor-a (TNF-a), a cytokine known to contribute to the pathogenesis in the early stages of diabetes development. LÄS MER
12. Cytokine regulation of pancreatic -cell function with special reference to the pathogenesis of type 1 diabetes
Sammanfattning : Cytokines produced by inflammatory cells have been implicated in the pathogenesis of type 1 diabetes. The overall aim of the present work was to test how different cytokines, supposed to be present in the insulitic lesion, could influence the function of islets of Langerhans. LÄS MER
13. Anomalies in humoral immunity in the NOD mouse : contribution to the progression of type 1 diabetes
Sammanfattning : The non-obese diabetic (NOD) mouse is widely used model Type 1 diabetes (T1D), a chronic inflammatory disease characterized by destruction of the insulin producing β cells in the islets of Langerhans by immune cells. The classical symptoms include increased glucose levels in urine and blood, frequent urination and enhanced thirst. LÄS MER
14. Diabetes in 3D : β-cell mass assessments in disease models & evaluation of SPECT based imaging
Sammanfattning : Diabetes is a rapidly growing disease with 415 million affected adults worldwide. The pancreatic endocrine cells, most importantly the insulin producing β-cells, play an important role in regulating blood glucose homeostasis. LÄS MER