Sökning: "radiotracers"

Visar resultat 1 - 5 av 28 avhandlingar innehållade ordet radiotracers.

  1. 1. Diabetes in 3D : β-cell mass assessments in disease models & evaluation of SPECT based imaging

    Författare :Saba Parween; Ulf Ahlgren; Helena Edlund; Eckhard Lammert; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Optical projection tomography; Diabetes; β-cell mass; disease etiology; 3D imaging; radiotracers; Single photon emission computed tomography; molekylär medicin genetik och patologi ; molecular medicine  genetics and pathology ;

    Sammanfattning : Diabetes is a rapidly growing disease with 415 million affected adults worldwide. The pancreatic endocrine cells, most importantly the insulin producing β-cells, play an important role in regulating blood glucose homeostasis. LÄS MER

  3. 2. Theranostic Targeting of GRPR and PSMA in Prostate Cancer

    Författare :Ayman Abouzayed; Anna Orlova; Ulrika Rosenström; Anzhelika Vorobyeva; Bogdan Mitran; Cristina Müller; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; prostate cancer; gastrin-releasing peptide receptor GRPR ; prostate-specific membrane antigen PSMA ; nuclear medicine; molecular imaging; radiotracers; theranostics; Farmaceutisk vetenskap; Pharmaceutical Science; Oncology; Onkologi;

    Sammanfattning : This thesis is based on five original articles that investigated the theranostics of prostate cancer by gastrin-releasing peptide receptor (GRPR) and prostate-specific membrane antigen (PSMA) targeting. GRPR and PSMA are two extensively evaluated prostate cancer cell markers due to their overexpression in the majority of prostate cancer samples. LÄS MER

  4. 3. Pharmacological properties of radiotracers that measure p-glycoprotein function and density

    Författare :Pavitra Kannan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Energy-dependent transporters of the ATP-binding cassette (ABC) family regulate the movement of molecules across cellular membranes. Several of these transporters are expressed in the endothelial cells of brain microvessels (blood-brain barrier) to protect brain tissue from exposure to toxins in the blood. LÄS MER

  5. 4. Synthesis of 11C and 18F labelled radiotracers for applications in steroid-related biological systems

    Författare :Pelle Lidström; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; Kemi; Organisk;

    Sammanfattning : .... LÄS MER

  7. 5. Targeting EGFR and VEGFR2 tyrosine kinases with positron emission tomography : evaluation of two radiotracers

    Författare :Erik Samén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Receptor tyrosine kinases (RTKs) are commonly involved in the development, growth and spread of cancer. Targeted therapy with tyrosine kinase inhibitors (TKIs) has proven a successful treatment strategy against cancers in which growth is dependent on the expression of these receptors. LÄS MER