Sökning: "individual radiosensitivity"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden individual radiosensitivity.

1. 1. Biomarkers of oxidative stress and their application for assessment of individual radiosensitivity

   Författare :Siamak Haghdoost; Mats Harms-Ringdahl; Steffen Loft; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oxidative stress; 8-oxo-dG; 8-oh-dG; Radiosensitivity; Toxicology; Toxikologi;

   Sammanfattning : Radiotherapy is one of the most common therapeutic methods for treatment of many types of cancer. Despite many decades of development and experience there is much to improve, both in efficacy of treatment and to decrease the incidences of adverse healthy tissue reactions. LÄS MER

3. 2. In vitro and in vivo aspects of intrinsic radiosensitivity

   Författare :Karl Brehwens; Andrzej Wojcik; Siamak Haghdoost; Wolfgang Dörr; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Radiation biology; changing dose rates; cytogenetics; hypothermia; X-rays; radiotherapy; osteoradionecrosis; biomarkers; oxidative stress; individual radiosensitivity; molekylär biovetenskap; Molecular Biosciences;

   Sammanfattning : This thesis focuses on how physical and biological factors influence the outcome of exposures to γ/X-rays. That the dose rate changes during real life exposure scenarios is well-known, but radiobiological data from exposures performed at increasing or decreasing dose rates is lacking. LÄS MER

4. 3. Tumor radiosensitivity and proliferation as parameters for optimizing radiotherapy

   Författare :Mattias Hedman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Radiotherapy is a widely used method to treat malignant tumors. However, the sensitivity to the treatment varies between tumors, and local tumor control is not always achieved. The balance between treatment success and the side effects of the treatment affords important information for developing treatment schedules at patient population level. LÄS MER

5. 4. Description and prediction of clinical radiosensitivity : emphasis on normal tissue reactions

   Författare :Roger Tell; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Radiotherapy; radiosensitivity; normal tissue; thyroid; cell cycle; lung injury;

   Sammanfattning : There is a range in the severity of normal tissue reactions observed when cancer patients receive radiotherapy (RT). The limits of dosage in RT have empirically been set by doses that have caused severe reactions in the most sensitive patients. The understanding of factors governing variations of radiosensitivity is therefore very important in RT. LÄS MER

7. 5. Biomolecular markers in head and neck cancer

   Författare :Eva Lindell Jonsson; Göran Laurell; Karin Nylander; Marika Nestor; Linda Marklund; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Head and neck cancer; Biomolecular markers; Radiation; Radiation-induced mucositis; Oral Tongue Squamous Cell Carcinoma; Metabolomics; EGFR; Hyaluronan; Mast cells; Neutrophils; Oto-Rhino-Laryngology; Oto-rhino-laryngologi;

   Sammanfattning : Head and neck cancer is a heterogeneous group of tumours, of which certain subgroups such as cancer of the mobile tongue frequently are associated with a relatively poor prognosis due to the high risk of regional failure and mortality rates that haven’t improved in a significant way over the last 3 decades, despite advancements in both diagnostics and treatment.Today we lack means to assess the biological aggressiveness of each individual tumour, which varies largely. LÄS MER