Sökning: "homologue prediction"
Visar resultat 1 - 5 av 6 avhandlingar innehållade orden homologue prediction.
1. Evolution of protein and non-coding RNA genes studied with comparative genomics
Sammanfattning : The identification of protein and non-coding RNA (ncRNA) genes is one important step in the analysis of a genome. This thesis focuses on the identification and analysis of proteins and ncRNAs homologues by exploiting a variety of computational methods in order to reach conclusions as to their structure, function, evolution and regulation. LÄS MER
2. Mismatch repair deficiency in colorectal cancer : prognosis and prediction for basic treatment strategies
Sammanfattning : Colorectal cancer (CRC) remains a significant healthcare problem worldwide, being the third most common cancer and the fourth most frequent cause of cancer death. Environmental and dietary factors such as alcohol abuse, cigarette smoking, and genetic predisposition seem to constitute the main aetiologies. LÄS MER
3. From protein sequence to structural instability and disease
Sammanfattning : A great challenge in bioinformatics is to accurately predict protein structure and function from its amino acid sequence, including annotation of protein domains, identification of protein disordered regions and detecting protein stability changes resulting from amino acid mutations. The combination of bioinformatics, genomics and proteomics becomes essential for the investigation of biological, cellular and molecular aspects of disease, and therefore can greatly contribute to the understanding of protein structures and facilitating drug discovery. LÄS MER
4. Structural Information and Hidden Markov Models for Biological Sequence Analysis
Sammanfattning : Bioinformatics is a fast-developing field, which makes use of computational methods to analyse and structure biological data. An important branch of bioinformatics is structure and function prediction of proteins, which is often based on finding relationships to already characterized proteins. LÄS MER
5. The use of structural information to improve biological sequence similarity searches
Sammanfattning : Bioinformatics is a fast-developing field that make use of computational methods to analyse and structure biological data. An important branch of bioinformatics is structure and function prediction of proteins. To determine the structure of a protein is a crucial part in the characterisation of the molecule. LÄS MER