Sökning: "glycine transporter inhibitor"

Hittade 3 avhandlingar innehållade orden glycine transporter inhibitor.

  1. 1. Studies on new pharmacological treatments for alcohol dependence - and the importance of objective markers of alcohol consumption

    Författare :Andrea deBejczy; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; alcohol dependence; mirtazapine; varenicline; org 25935; alcohol markers; phosphatidylethanol; randomized controlled clinical trials RCT ; treatment; glycine transporter inhibitor; nAChR;

    Sammanfattning : This thesis will guide you through three randomized controlled trials (RCT) on three pharmacotherapies for alcohol dependence; the antidepressant drug mirtazapine, the smoking cessation drug varenicline and the glycine-uptake inhibitor Org 25935. The mirtazapine study was an investigator initiated single-center harm-reduction study with alcohol consumption measured by self-report in a diary as main outcome. LÄS MER

  3. 2. Preclinical investigations of GlyT-1 inhibition as a new concept for treatment of alcohol dependence

    Författare :Helga Lidö Höifödt; Göteborgs universitet; []
    Nyckelord :Psykiatri experimentell ; Neurofarmakologi; alcohol; dependence; dopamine; GlyT-1 inhibition; nucleus accumbens; reward;

    Sammanfattning : Alcohol addiction and abuse is a main contributor to the global burden of disease and is a high public health priority. Alcohol addiction is a chronically relapsing neurobiological disorder affecting multiple neurotransmitter systems. LÄS MER

  4. 3. Modulation of prefrontal glutamatergic transmission and 'atypicality' of antipsychotic drugs

    Författare :Åsa Konradsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The glutamate hypothesis of schizophrenia suggests a relationship between hypoactive NMDA receptor-mediated glutamatergic transmission and the pathophysiology of schizophrenia. Previous results have demonstrated that atypical (e.g. clozapine, risperidone, and olanzapine), but not typical (e. LÄS MER