Sökning: "gene sequence"

Visar resultat 1 - 5 av 859 avhandlingar innehållade orden gene sequence.

  1. 1. Probabilistic Modelling of Domain and Gene Evolution

    Författare :Sayyed Auwn Muhammad; Jens Lagergren; Bastien Boussau; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Phylogenetics; Phylogenomics; Evolution; Domain Evolution; Gene tree; Domain tree; Bayesian Inference; Markov Chain Monte Carlo; Homology Inference; Gene families; C2H2 Zinc-Finger; Reelin Protein; Computer Science; Datalogi;

    Sammanfattning : Phylogenetic inference relies heavily on statistical models that have been extended and refined over the past years into complex hierarchical models to capture the intricacies of evolutionary processes. The wealth of information in the form of fully sequenced genomes has led to the development of methods that are used to reconstruct the gene and species evolutionary histories in greater and more accurate detail. LÄS MER

  3. 2. TARP Promoter-Based Prostate Cancer Gene Therapy : From Development to Application

    Författare :Wing-Shing Cheng; Magnus Essand; Thomas H. Tötterman; Cecilia Lundberg; Uppsala universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Genetic engineering; TARP; PPT; TSTA; promoter; gene regulation; prostate specificity; hormone- independent; adenovirus; prostate cancer; gene therapy; conditionally replicating adenovirus; Genteknik; Genetic engineering including functional genomics; Genteknik inkl. funktionsgenomik;

    Sammanfattning : Prostate cancer is one leading cause of cancer-related death among men in Western countries. The standard therapies for localized prostate cancer include radical prostatectomy and radiation therapy. Such measures are relatively effective in the short term, but many patients ultimately relapse. LÄS MER

  4. 3. Using Trees to Capture Reticulate Evolution : Lateral Gene Transfers and Cancer Progression

    Författare :Ali Tofigh; Jens Lagergren; Mike Steel; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Lateral Gene Tranfer; Horizontal Gene Transfer; Cancer Progression; Bioinformatics; Bioinformatik; Computer science; Datalogi;

    Sammanfattning : The historic relationship of species and genes are traditionally depicted using trees. However, not all evolutionary histories are adequately captured by bifurcating processes and an increasing amount of research is devoted towards using networks or network-like structures to capture evolutionary history. LÄS MER

  5. 4. Tripeptidyl-Peptidase II : Structure, Function and Gene Regulation

    Författare :Ann-Christin Lindås; Birgitta Tomkinson; Mikael Widersten; Ralf Morgenstern; Uppsala universitet; []
    Nyckelord :Biochemistry; gene regulation; protein expression; enzyme kinetics; tripeptidyl-peptidase II; proteasome; intracellular protein degradation; exopeptidase; Biokemi;

    Sammanfattning : The protein degradation process is of vital importance for the cell to maintain cellular functions. An important enzyme in this process is the multimeric tripeptidyl-peptidase II (TPP II). It removes tripeptides from a free N-terminus of the substrates. LÄS MER

  7. 5. Computational Problems in Modeling Evolution and Inferring Gene Families

    Författare :Mehmood Alam Khan; Lars Arvestad; Jens Lagergren; Christophe Dessimoz; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Evolution; Phylogenetics; Lateral Gene Transfer; Gene Families; Clustering; Datalogi; Computer Science;

    Sammanfattning : Over the last few decades, phylogenetics has emerged as a very promising field, facilitating a comparative framework to explain the genetic relationships among all the living organisms on earth. These genetic relationships are typically represented by a bifurcating phylogenetic tree — the tree of life. LÄS MER