Sökning: "exosome"

Visar resultat 11 - 15 av 35 avhandlingar innehållade ordet exosome.

1. 11. The RNA exosome and the maintenance of genome integrity

   Författare :Judit Domingo Prim; Neus Visa; Andrés Aguilera; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; EXOSC10; RRP6; DNA damage; diRNA; DDRNA; DNA end resection; homologous recombination; molekylär biovetenskap; Molecular Bioscience;

   Sammanfattning : The RNA exosome is a ribonucleolytic complex that acts on different RNA substrates and plays important roles in RNA metabolism. In recent years, the synthesis and the processing of RNA have been directly linked to the integrity of the genome. LÄS MER

3. 12. Exploring human variations by droplet barcoding

   Författare :Pontus Höjer; Afshin Ahmadian; Pelin Sahlén; Lars Feuk; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; droplets; linked-read sequencing; DNA barcoding; proteomics; genomics; single cell; single extracellular vesicle; single exosome; pipelines; Biotechnology; Bioteknologi;

   Sammanfattning : Biological variations are being explored at ever-increasing rates through the rapid advancement of analytical techniques. Techniques like massively parallel sequencing empower scientists to accurately differentiate individuals’ genetic compositions, cellular functionalities, and healthy tissue from diseased. LÄS MER

4. 13. Detection of Bio-analytes with Streaming Current : From Fundamental Principles to Novel Applications

   Författare :Siddharth S. Sahu; Apurba Dev; Shi-Li Zhang; Michel Calame; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Streaming current; Electrokinetic biosensor; Size and Charge effects; membrane protein profiling of extracellular vesicles; sandwich immunoassay; charge-labelled antibodies; multiplexed detection; exosome heterogeneity;

   Sammanfattning : A biosensor based on streaming current is a new and relatively unexplored subject with significant potential. This thesis attempts to gain a deeper understanding of the governing principles, and then exploit them to further improve its performance as well as develop novel applications. LÄS MER

5. 14. Droplet Microfluidics reverse transcription and PCR towards Single Cell and Exosome Analysis

   Författare :Lovisa Söderberg; Helene Andersson Svahn; Håkan Jönsson; Valérie Taly; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Droplet microfluidics; Reverse transcription; Droplet PCR; High Throughput biology; Single cell Analysis; Exosomes; Bioteknologi; Biotechnology;

   Sammanfattning : Miniaturization of biological analysis is a trend in the field of biotechnology aiming to increase resolution and sensitivity in biological assays. Decreasing the reaction volumes to analyze fewer analytes in each reaction vessel enables the detection of rare analytes in a vast background of more common variants. LÄS MER

7. 15. Extracellular Vesicles and RNA interference in tumors

   Författare :Taral R Lunavat; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melanoma; Therapeutics; Exosome-mimetic nanovesicles; Apoptotic bodies; Microvesicles; Exosomes;

   Sammanfattning : Extracellular vesicles (EVs) including apoptotic bodies (ABs), microvesicles (MVs), exosomes (EXOs) and cell derived artificial nanovesicles (NVs) are important mediators of cell-to-cell communication, in part by transferring bioactive molecules such as DNA, mRNA, miRNA, siRNA, proteins, and lipids. These EVs are released by many cell types, including melanoma cells, and are found in many body fluids. LÄS MER