Sökning: "endocrine tumor"

Visar resultat 16 - 20 av 77 avhandlingar innehållade orden endocrine tumor.

1. 16. Multiple endocrine neoplasia type 1 : clinical and molecular characterization

   Författare :Bin Tean Teh; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :MEN1; PYGM; loss of heterozygosity; thymic carcinoid; HPT-JT; HRPT2; FIHP; familial acromegaly; tumor suppressor gene.;

   Sammanfattning : This thesis is based on clinicopathologic and genetic studies of MEN1 and MEN1-like syndromes. Linkage to the MENl locus in chromosome 11q13 was confirmed in the largest known MEN1 family and 5 Swedish MEN1 families. An accuracy of >99. LÄS MER

3. 17. Molecular studies of multiple endocrine neoplasia type 1 (MEN1)

   Författare :Shideh Khodaei-O'Brien; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :genetics; MEN1; cancer; tumor suppressor gene; cDNA selection; mutation; menin; ortholog; evolution; conservation; expression; RNA; protein; RT-PCR;

   Sammanfattning : Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant familial cancer syndrome characterized by tumors of the parathyroids, the endocrine pancreas and anterior pituitary. The MEN1 locus has been previously localized to chromosome 11q13 and subsequently a MEN1 minimum region was defined by a combination of linkage and tumor deletion studies. LÄS MER

4. 18. Functional studies of the multiple endocrine neoplasia type 1 gene

   Författare :Lovisa Bylund; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :MEN1; menin; tumor suppressor gene; cancer; RNAi; promoter; expression; cytogenetic; microarray;

   Sammanfattning : The multiple endocrine neoplasia type 1 (MEN1, OMIM 131 100) syndrome is an autosomal dominant trait with a near 100% penetrance and with an estimated prevalence of 2-20/100 000. The syndrome is characterized by neoplasia affecting the parathyroid glands (90-97%), enteropancreatic endocrine tissues (30-80%) and the anterior pituitary gland (15-50%) but tumors arc also found in other, both endocrine and non endocrine tissues. LÄS MER

5. 19. Current Medical Treatment of Endocrine Pancreatic Tumors and Future Aspects

   Författare :Marie-Louise Fjällskog; Morten Vatn; Uppsala universitet; []
   Nyckelord :Medical sciences; pancreatic tumors; somatostatin analogs; cisplatin; etoposide; somatostatin receptors; immunohistochemistry; tyrosine kinase receptors; platelet-derived growth factors receptors PDGFRs ; c-kit; epidermal growth factor receptor EGFR ; MEDICIN OCH VÅRD; alfa-interferon; MEDICINE; MEDICIN; Medicine; medicin;

   Sammanfattning : We treated 16 patients with somatostatin analogs combined with α-interferon and achieved a biochemical and/or radiological response in 56% (median duration 22 months). We consider this treatment a good alternative for patients who fail during chemotherapy or who do not want to/cannot receive cytotoxic drugs. LÄS MER

7. 20. Aspects of MEN1 Tumorigenesis in Endocrine Pancreas and Adrenal Glands

   Författare :Xia Chu; Kjell Öberg; Barbro Eriksson; Magnus Kjellman; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEN1; tumorigenesis; PNET; angiogenesis; adrenal glands; proteomic analysis; miRNA expression; Oncology; Onkologi;

   Sammanfattning : Multiple endocrine neoplasia syndrome type 1 (MEN1) is an autosomal dominantly inherited disease, which is described as an association of tumors mainly in endocrine organs, including pancreas and adrenal glands. Pancreatic neuroendocrine tumors (PNETs) are the most common cause of death in MEN1 patients. LÄS MER