Sökning: "MEN1"
Visar resultat 1 - 5 av 23 avhandlingar innehållade ordet MEN1.
1. Aspects of MEN1 Tumorigenesis in Endocrine Pancreas and Adrenal Glands
Sammanfattning : Multiple endocrine neoplasia syndrome type 1 (MEN1) is an autosomal dominantly inherited disease, which is described as an association of tumors mainly in endocrine organs, including pancreas and adrenal glands. Pancreatic neuroendocrine tumors (PNETs) are the most common cause of death in MEN1 patients. LÄS MER
2. Molecular Genetic Studies of Sporadic and MEN1-Associated Endocrine Pancreatic Tumors
Sammanfattning : Pancreatic endocrine tumors (PETs) may cause typical syndromes of hormone excess, or appear clinically non-functioning without hormonal symptoms. PETs occur sporadically, in association with the multiple endocrine neoplasia type 1 (MEN1) syndrome, or rarely the von Hippel-Lindau syndrome. LÄS MER
3. Genetic studies of endocrine abdominal tumors
Sammanfattning : Pancreatic endocrine tumors (PETs) occur sporadically or in the familial multiple endocrine neoplasia type 1 (MEN1) syndrome, whereas midgut carcinoids are nonfamilial, malignant endocrine tumors of the intestine. For these tumor entities morphological criteria are of limited use for prognostic prediction and selection of treatment. LÄS MER
4. Pancreatic Endocrine Tumourigenesis : Genes of potential importance
Sammanfattning : Understanding signalling pathways that control pancreatic endocrine tumour (PET) development and proliferation may reveal novel targets for therapeutic intervention. The pathogenesis for sporadic and hereditary PETs, apart from mutations of the MEN1 and VHL tumour suppressor genes, is still elusive. LÄS MER
5. Molecular studies of endocrine tumors : Insights from genetics and epigenetics
Sammanfattning : Endocrine tumors may be benign or malignant and may occur in any of the hormone producing tissues. They share several biological characteristics, including a low mutation-burden, and may co-occur in several hereditary tumor syndromes. The aim of this thesis was to identify genetic and epigenetic aberrations in endocrine tumors. LÄS MER