Sökning: "conformational polymorphism"

Visar resultat 11 - 14 av 14 avhandlingar innehållade orden conformational polymorphism.

  1. 11. Identification and characterization of novel mammalian alcohol dehydrogenases

    Författare :Patrik Strömberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The vertebrate medium chain alcohol dehydrogenases are dimeric zinc metalloenzymes that catalyze the reversible oxidation/reduction of alcohols/aldehydes using NAD+/NADH as coenzyme. In mammals, six classes of ADH have been defined (ADH1-ADH6) whereof five have been identified in humans. LÄS MER

  3. 12. Alterations of the short arm of chromosome 9p in lymphoid malignancies

    Författare :Mats Heyman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Malignant disease evolves through the successive accumulation of genetic lesions affecting growth-controlling genes in the cell-clone undergoing malignant transformation. 9p21 has long been suspected to harbour a tumour suppressor gene, because of frequent deletions of this region in malignancies including acute lymphocytic leukaemia (ALL). LÄS MER

  4. 13. Molecular studies in breast cancer susceptibility genes

    Författare :Jindong Chen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :familial breast cancer; breast cancer susceptibility gene; BRCA1; BRCA2; ATM; TP53; PTEN MMAC1; STK11 LKB1; gene mutation; mutation screening; LOH;

    Sammanfattning : Breast cancer is the most common malignancy among women, with a cumulative risk of approximately 12% by the age of 85. Of the breast cancer cases, 5-10% are hereditary. LÄS MER

  5. 14. Inflammatory transcription factors in atherosclerosis

    Författare :Wolfgang Dichtl; Lund Medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiovascular system; Kardiovaskulära systemet;

    Sammanfattning : Transcription factors such as nuclear factor-kB (NF-kB), activator protein-1 (AP-1) and peroxisome proliferator-activated receptors (PPARs) may play important roles in atherogenesis, by regulating chronic subclinical vascular inflammation. In the first study, we showed that VLDL activates the proinflammatory transcription factor NF-kB in endothelial cells both in vitro and in vivo. LÄS MER