Sökning: "coenzyme A"

Visar resultat 1 - 5 av 54 avhandlingar innehållade orden coenzyme A.

  1. 1. Acyl-CoA thioesterases : auxiliary enzymes in peroxisomal lipid metabolism

    Författare :Maria A K Westin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Peroxisomes are small organelles essential for life, which carry out a variety of functions mostly related to lipid metabolism, including α- and β-oxidation as well as the first steps of plasmalogen biosynthesis. Peroxisomal β-oxidation metabolizes many different lipids including very long-chain fatty acids, dicarboxylic fatty acids, branched-chain fatty acids, eicosanoids and certain xenobiotic fatty acids. LÄS MER

  3. 2. Refined crystal structures of Zn(II)- and Cu(II)-alcohol dehydrogenase : a comparative study

    Författare :Salam al-Karadaghi; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; strukturkemi; Structural Chemistry;

    Sammanfattning : The crystal structure of the ternary complex of horse liver alcohol dehydrogenase (LADH) with the coenzyme NADH and inhibitor dimethyl sulphoxide (DMSO) (space group PI) has been refined by simulated annealing with molecular dynamics and restrained positional refinement using the program system XPLOR. The resulting crystallographic R- factor is 17. LÄS MER

  4. 3. Formyl-coenzyme : a transferase, structure and enzymatic mechanism

    Författare :Stefano Ricagno; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :X-ray crystallography; oxalate degradation; Oxalobacter; CoA transferase; interlocked dimer; anhydride.;

    Sammanfattning : Background: Formyl-CoA transferase (Frc) is the first enzyme in a two enzyme pathway responsible for oxalate degradation in Oxalobacter formigenes. This bacterium is a constitutive part of human intestinal flora. Its role as an oxalate scavenger is very important, reports have shown a strong connection between the disappearance of 0. LÄS MER

  5. 4. Functional characterization of a peroxisomal acyltransferase gene family

    Författare :Sarah-Jayne Reilly; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Peroxisomes are cell organelles that play an important role in the metabolism of a variety of lipids including very long chain fatty acids, dicarboxylic acids, bile acids, and xenobiotic carboxylic acids. The metabolism of lipids in peroxisomes requires the concerted efforts of many different enzymes, which includes members of the type I acyl-CoA thioesterase/acyltransferase protein family and the nudix hydrolases. LÄS MER

  7. 5. The role of HMG-coenzyme A reductase (HMGCR) and statin medication in the Central Nervous System : Cognitive Functions, Metabolism, Feeding and Sleep Behaviour

    Författare :Ahmed Alsehli; Helgi B. Schiöth; Michael J. Williams; Heinrich Dircksen; Uppsala universitet; []
    Nyckelord :Statin; cardiovascular disease; HMGCR; PCSK9; sleep; insomnia; circadian; Chronotype; feeding;

    Sammanfattning : Millions of people are currently on statin medications (HMGCR inhibitors) to prevent cardiovascular diseases. Despite considerable central nervous system expression, little is known about HMGCR function in the brain. LÄS MER