Sökning: "clopidogrel poor response"

Hittade 4 avhandlingar innehållade orden clopidogrel poor response.

  1. 1. Platelet Inhibition in Coronary Artery Disease – Mechanisms and Clinical Importance : Studies with Focus on P2Y12 Inhibition

    Författare :Christoph Varenhorst; Stefan James; Agneta Siegbahn; Lars Wallentin; Steen Dalby Kristensen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; coronary artery disease; myocardial infarction; acute coronary syndromes; stent thrombosis; P2Y12 inhibitors; thienopyridines; clopidogrel poor response; clopidogrel; prasugrel; Cardiology; Kardiologi; Kardiologi; Cardiology;

    Sammanfattning : Despite the currently recommended dual antiplatelet treatment (DAT) with aspirin and P2Y12 inhibition in patients with coronary artery disease (CAD) there is a risk of adverse clinical outcome. Pharmacodynamic (PD) poor response to clopidogrel occurs in ~ 30% of clopidogrel-treated patients and is associated with an increased risk of recurrent thrombotic events. LÄS MER

  3. 2. Studies on platelet function and microvesicles in acute coronary syndrome

    Författare :Sam Kafian; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : INTRODUCTION: The cornerstone of treatment of acute coronary syndrome (ACS) is percutaneous coronary intervention (PCI) and dual antiplatelet therapy (DAT) with aspirin and the ADP-receptor inhibitor clopidogrel. However, some ACS patients will suffer from recurrent cardiovascular events, and it has been shown that this may partly be due to an insufficient antiplatelet response to DAT. LÄS MER

  4. 3. Experimental and Clinical Studies on Platelet Receptors in Cardiovascular Disease

    Författare :Oscar Braun; Kardiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; inflammation; athersosclerosis; platelets; thrombosis; Cardiovascular system; Kardiovaskulära systemet;

    Sammanfattning : The crucial role of platelets in maintaining primary hemostais has been evident for a long time and there is now also mounting evidence for their involvement in inflammation. In combination with aspirin, inhibition of the platelet P2Y12 ADP receptor with clopidogrel has become a cornerstone in the antiplatelet in acute coronary syndromes. LÄS MER

  5. 4. Platelet function and thrombin generation in ischemic stroke : clinical correlates and prognostic importance

    Författare :Annika Lundström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Platelet function is central to atherothombotic diseases and antiplatelet agents prevent non-cardioembolic ischemic stroke (IS). Individual differences in platelet reactivity may limit the response to antiplatelet treatment, leading to so-called high on-treatment platelet reactivity (HPR). LÄS MER