Sökning: "artemisinins"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet artemisinins.

  1. 1. Clinical pharmacokinetics and pharmacodynamics of antimalarial combination therapy

    Författare :Sofia Friberg Hietala; Göteborgs universitet; []
    Nyckelord :pharmacokinetics; pharmacodynamics; antimalarials; artemisinins;

    Sammanfattning : In the face of growing drug resistance, the World Health Organization (WHO) has issued recommendations strongly encouraging the use of combination therapies to combat uncomplicated malaria. Amongst the most effective treatments are those combining an artemisinin derivative with a longer acting component such as amodiaquine, lumefantrine or piperaquine. LÄS MER

  3. 2. Experimental pharmacodynamic and kinetic studies related to new combination therapies against P. falciparum malaria

    Författare :Seema Gupta; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Artemisinin (ART) class of compounds are of special interest due to their rapid onset of action and high activity against multidrug resistant malaria. The major drawback in monotherapy with ART and its derivatives is the high rate of recrudescent infection. LÄS MER

  4. 3. Pharmacokinetics, drug metabolism and clinical effects of the antimalarial artemisinin : Time-dependencies and modeling aspects

    Författare :Ulrika Sigrid Helena Svensson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; Biopharmaceutics; Biofarmaci;

    Sammanfattning : The mechanism behind artemisinin time-dependent bioavailability was investigated using a rat in-situ single-pass jejunal perfusion technique. The consequence for drug combination therapy was studied in healthy volunteers and in patients with Plasmodium falciparum. LÄS MER

  5. 4. Molecular basis for the mechanism of action and resistance to artemisinin combination therapy in Plasmodium falciparum

    Författare :Pedro Ferreira; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Plasmodium falciparum;

    Sammanfattning : Malaria, caused by the Plasmodium falciparum parasite, remains a leading cause of death among children in Africa. To improve treatment efficacy and delay development and spread of antimalarial drug resistance artemisinin artemisinin-based combination therapy (ACT) is now globally recommended as first-line treatment of uncomplicated P. LÄS MER

  7. 5. The molecular basis of Plasmodium falciparum resistance to the antimalarial lumefantrine

    Författare :Christin Sisowath; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Malaria control is compromised by the development and spread of Plasmodium falciparum resistance to antimalarial drugs, which has caused an increase in malaria related morbidity and mortality. Artemisinin based combination therapy (ACT) has been implemented in almost all malaria endemic areas in an attempt to suppress drug resistance. LÄS MER