Sökning: "arsenic resistance"

Visar resultat 6 - 10 av 13 avhandlingar innehållade orden arsenic resistance.

  1. 6. Identification and Functional Significance of Aberrant Long Non-coding RNAs in Acute Myeloid Leukemia : Biological and Prognostic Implications

    Författare :Anne H. Neddermeyer; Sören Lehmann; Jonas Larsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acute myeloid leukemia AML ; hematopoiesis; long non-coding RNAs lncRNAs ; RNA- and CAGE-sequencing; CRISPRi; CRISPR-Cas9; NEAT1; APL; NPM1; IDH2; all-trans retinoic acid; arsenic trioxide; venetoclax; drug resistance and sensitivity; prognosis; RADICL-sequencing; Molekylär medicin; Molecular Medicine;

    Sammanfattning : Acute myeloid leukemia (AML) is the most frequently diagnosed type of acute leukemia in adults. It commonly affects people aged 60 or older, as incidence increases with age, and it is characterized by the accumulation of immature hematopoietic progenitor cells in the bone marrow. LÄS MER

  3. 7. Characterization and solidification of arsenic-rich cyanided tailings

    Författare :Roger Hamberg; Lena Sultan; Luleå tekniska universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Applied Geology; Tillämpad geologi;

    Sammanfattning : Information on the occurrence of As species and iron sulphide minerals in tailings is essential for predicting therelease of As over extended period of time. Tailings originating from a goldmine in northern Sweden with low content of trace elements except for As were used for this purpose. The dominating sulphides were pyrrhotite and arsenopyrite. LÄS MER

  4. 8. Clinical and Experimental Studies in Chronic Myeloid Leukemia : Studies of Treatment Outcome, In Vitro Cellular Drug Resistance and Gene Expression

    Författare :Ulla Olsson-Strömberg; Bengt Simonsson; Elin Lindhagen; Gisela Barbany; Johan Richter; Uppsala universitet; []
    Nyckelord :Medicine; chronic myeloid leukemia; adult; stem cell transplantation; mobilization of Ph-negative stem cells; in vitro assay; imatinib; gene expression; Medicin;

    Sammanfattning : The aims of the studies described in the thesis were to investigate different treatment strategies in chronic myeloid leukemia (CML) patients. Furthermore, activity of imatinib was investigated by in vitro cytotoxicity assay, and the gene expression pattern in interferon treated patients. LÄS MER

  5. 9. In vitro studies of retinoids and arsenic in non-M3 acute myeloid leukemia

    Författare :Sören Lehmann; Karolinska Institutet; Karolinska Institutet; Sweden Stockholm Huddinge University Hospital Department of Medicine; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Despite advances in the treatment of patients with acute myeloid leukemia (AML), the majority of the patients will die from their disease. The current intensive therapy for AML is also complicated my substantial morbidity and mortality and, as a result, many patients cannot be given the most effective therapy. LÄS MER

  7. 10. Bioremediation of Toxic Metals for Protecting Human Health and the Ecosystem

    Författare :Aminur Rahman; Abul Mandal; Jana Jass; Björn Olsson; Pawel Kaszycki; Örebro universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Heavy Metals; Pollution; Accumulation; Remediation; Human Health; Bacteria; Genome Sequencing; de novo Assembly; Gene Prediction; Biology; Biologi; Bioteknik;

    Sammanfattning : Heavy metal pollutants, discharged into the ecosystem as waste by anthropogenic activities, contaminate drinking water for millions of people and animals in many regions of the world. Long term exposure to these metals, leads to several lethal diseases like cancer, keratosis, gangrene, diabetes, cardio- vascular disorders, etc. LÄS MER