Sökning: "alcohol marker"

Visar resultat 6 - 10 av 42 avhandlingar innehållade orden alcohol marker.

1. 6. The Relation between Serotonergic Biomarkers and Behaviour : – studies on human primates, non-human primates and transgenic mice

   Författare :Hanna-Linn Wargelius; Dan Larhammar; Lars Oreland; Claudia Fahlke; Elias Eriksson; Uppsala universitet; []
   Nyckelord :Serotonin; MAO-A; 5-HTT; MAO-B; alcohol; ADHD; MEDICINE; MEDICIN; Medicin; Medicine; Neuroscience; Neurovetenskap;

   Sammanfattning : Rationale: The serotonergic system is involved in the modulation of emotion and plays an important role for personality and vulnerability for psychiatric disorders. In the papers included in this thesis, we investigate three biological factors that have been studied in relation to psychiatric symptoms: Platelet monoamine oxidase B (MAO-B) activity, and variations in the MAO-A and the serotonin transporter (5HTT) genes. LÄS MER

3. 7. Childhood bereavement, stress resilience, and cancer risk : an integrated register-based approach

   Författare :Beatrice Kennedy; Katja Fall; Fang Fang; Unnur Valdimarsdottír; Scott Montgomery; Meena Kumari; Örebro universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; alcohol; bereavement; cancer; drug use; epidemiology; health behaviour; psychological resilience; smoking; stress;

   Sammanfattning : Accumulating evidence suggests that psychosocial stress and susceptibility to stressful exposures – stress resilience – influence the risk of various health outcomes, but the potential link with cancer occurrence is unclear. The aims of this thesis were to test if loss of a close relative, a marker of severe psychological stress, and stress resilience measured during late adolescence are associated with cancer risk later in life, as well as to explore potential underlying mechanisms. LÄS MER

4. 8. Diet, lifestyle, antioxidants, and biomarkers of cancer risk - an epidemiological report from the Malmö Diet and Cancer cohort

   Författare :Peter Wallström; Nutritionsepidemiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; onkologi; cancer; Public health; epidemiology; Folkhälsa; epidemiologi; cancerology; Cytologi; oncology; Cytology; Alcohol; Obesity; Smoking; Autoantibodies; Glutathione S-transferase; Oxidative stress; Vitamin E; Carotene; Body composition; Vegetables; Fruits; Cross-sectional; Adult; Diet surveys;

   Sammanfattning : This thesis examines associations between a number of epidemiological or biological markers of cancer risk and oxidative stress, in order to achieve a better understanding of how diet, lifestyle, and genetic factors contribute to the occurrence of oxidative stress. Data from the Malmö Diet and Cancer (MDC) cohort was used. LÄS MER

5. 9. Phosphatidylethanol - formation and degradation in blood and organs

   Författare :Steina Aradottir; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diagnostik; Public health; Diagnostics; organs; blood; HPLC; in vitro; in vivo; human; rat; phosphatidylethanol; phospholipase D; alcohol; ethanol; epidemiology; Folkhälsa; epidemiologi;

   Sammanfattning : Phosphatidylethanol (PEth) is an abnormal phospholipid formed exclusively by the action of phospholipase D (PLD) in the presence of ethanol. The degradation of PEth is slow and due to its accumulation in some cells the possibility to use PEth as marker of ethanol intake has been proposed. LÄS MER

7. 10. Drug and alcohol induced hepatotoxicity

   Författare :Angelica Butura; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Hepatotoxicity; in vitro models; alcoholic liver disease; CYP2E1;

   Sammanfattning : Drug induced hepatotoxicity is the most common reason cited for withdrawal of already approved drugs from the market and accounts for more than 50 percent of cases of acute liver failure in the United States. Ethanol (EtOH) causes a further substantial amount of liver insufficiencies world wide. LÄS MER