Sökning: "adoptive immunotherapy"

Visar resultat 1 - 5 av 31 avhandlingar innehållade orden adoptive immunotherapy.

1. 1. Cancer Immunotherapy : Oncolytic viruses and CAR-T cells

   Författare :Jing Ma; Di Yu; Magnus Essand; Mia Phillipson; Mohanraj Ramachandran; Karl-Johan Malmberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer immunotherapy; Oncolytic viruses; chimeric antigen receptor CAR -T cells; Helicobacter pylori Neutrophil Activating Protein;

   Sammanfattning : Various forms of cancer immunotherapy have developed rapidly with improved survival and quality of life for cancer patients. Cancer immunotherapy aims to educate the patient’s immune system to eliminate cancer cells, including immune checkpoint inhibitors (ICIs), adoptive cell transfer (mostly T cells), oncolytic viruses (OVs) and cancer vaccines. LÄS MER

3. 2. Towards Immunotherapy of Midgut Carcinoid Tumors

   Författare :Sofia Vikman; Thomas Tötterman; Valeria Giandomenico; Bengt Widegren; Uppsala universitet; []
   Nyckelord :Immunology; midgut carcinoid; gene expression; immunotherapy; tumor antigen; VMAT-1; T cell; HLA-A*0201-binding peptide; IFNγ; regulatory T cell; Immunologi;

   Sammanfattning : Classical midgut carcinoids belong to neuroendocrine tumors of the gastroenteropancreatic tract (GEP-NETs) and are associated with serotonin overproduction. The term midgut is derived from the tumors’ embryological site of origin: enterochromaffin cells in the lower jejunum, ileum, caecum and the ascending colon. LÄS MER

4. 3. Adoptive T Cell Therapy of Viral Infection and Cancer : Ex vivo Expansion of Cytomegalovirus- and Prostate Antigen-specific T Cells

   Författare :Björn Carlsson; Magnus Essand; Thomas Tötterman; Malcolm Brenner; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; Immunotherapy; Adoptive T cell therapy; Dendritic cell; T cell; Tetramer; Cytomegalovirus; Transplantation; pp65; Prostate cancer; TARP; Prostate antigens; Immunologi; Immunology; Immunologi;

   Sammanfattning : The main focus of my thesis has been to develop protocols for generating antigen-specific cytotoxic T lymphocytes (CTLs) and T helper cells (TH) for adoptive transfer to treat cytomegalovirus (CMV) disease and prostate cancer. CMV viremia is a severe complication in immunocompromised stem cell transplanted patients. LÄS MER

5. 4. Novel immunotherapies for metastatic melanoma - from mouse models towards clinical trials

   Författare :Elin Forsberg; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metastatic melanoma; uveal melanoma; patient-derived xenograft; immune-humanized mouse model; immunotherapy; adoptive T cell therapy; tumor-infiltrating lymphocytes; chimeric antigen receptor T CAR-T cells;

   Sammanfattning : Immunotherapies including checkpoint blockade and adoptive T cell transfer (ACT) show great promise for the treatment of melanoma, with long-term effects in some patients. However, around half of the patients with metastatic malignant melanoma will not be cured with available therapies today, and these patients require other treatment strategies. LÄS MER

7. 5. Generation of Therapeutic T Cells for Prostate Cancer

   Författare :Ole Forsberg; Magnus Essand; Thomas Tötterman; Gustav Gaudernack; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; T cells; dendritic cells; peptides; cytomegalovirus; adenovirus; immunotherapy; Clinical immunology; Klinisk immunologi; Klinisk immunologi; Clinical Immunology;

   Sammanfattning : The work presented herein focuses on the activation of the adaptive immune system in order to develop T cell-based immunotherapy for viral infections and cancer. The main goal was to identify and activate viral or tumoral antigen-specific T cells by using different identification, isolation and stimulation techniques. LÄS MER