Sökning: "Zakaria Einbeigi"

Hittade 1 avhandling innehållade orden Zakaria Einbeigi.

1. 1. Hereditary breast and ovarian cancer in western Sweden with a special focus on BRCA1 3171ins5 mutation

   Författare :Zakaria Einbeigi; Göteborgs universitet; []
   Nyckelord :BRCA1 gene; breast neoplasm; ovarian neoplasm; hereditary; haplotype;

   Sammanfattning : Aims: To describe the phenotype and geographic distribution of the western Swedish founder mutation BRCA1 3171ins5, evaluate the reliability of mutation analysis of this mutation on archival material, analyse the haplotype for founder effects in families with BRCA1 3171ins5 mutation, estimate the age of this mutation and evaluate whether the occurrence of both breast and ovarian cancers in the same women may be a marker of a BRCA gene mutation. Materials and methods: The first study was based on 16 families with BRCA1 3171ins5 mutation and the second study was based on 18 families with the same mutation. LÄS MER