Sökning: "Spongiform encephalopathy"

Hittade 4 avhandlingar innehållade orden Spongiform encephalopathy.

  1. 1. Interactions of Prion Proteins and PrP-derived Peptides in Scrapie infection

    Författare :Kajsa Löfgren Söderberg; Astrid Gräslund; Marcus Fändrich; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Spongiform encephalopathy; Creutzfeldt-Jakob disease; Amyloidosis; Neurodegeneration; Cell penetrating peptide; Protein Transduction Domain; Heparan sulfate; Proteoglycan; Glypican; Src family kinase; Fyn; Biochemistry; Biokemi; Biochemistry; biokemi;

    Sammanfattning : Prion diseases are fatal and incurable spongiform encephalopathies that occur amongst mammals. The central pathological event is the misfolding of the cellular prion protein (PrPC) into an amyloid, neurotoxic isoform called scrapie (PrPSc). PrPSc is the main, or sole, constituent of infectious prions. LÄS MER

  3. 2. Djurens skepnader : Närhet och distans i diskurs och livsvärld

    Författare :Jutta Falkengren; Humanekologi; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Cultural anthropology; cattle; human-animal relations; animal farming; ethnology; Kulturantropologi; etnologi;

    Sammanfattning : This dissertation is concerned with the relationship between humans and animals. In particular, it explores human relations to farm animals, and especially cattle. The empirical and theoretical work is concerned with how animals appear in discourses and how they form part of human life worlds. LÄS MER

  4. 3. Conjugated Polymers, Amyloid Detection and Assembly of Biomolecular Nanowires

    Författare :Anna Herland; Olle Inganäs; Samuel I. Stupp; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Conjugated Polymers; Amyloid Fibrils; Nanowires; Self-Assembly; Sensor; Amyloid Detection; Physics; Fysik;

    Sammanfattning : The research field of conjugated polymers has grown due to the optical and electronic properties of the material, useful in applications such as solar cells and printed electronics, but also in biosensors and for interactions with biomolecules. In this thesis conjugated polymers have been used in two related topics; to detect conformational changes in proteins and to assemble the polymers with biomolecules into nanowires. LÄS MER

  5. 4. Proislet Amyloid Polypeptide (proIAPP) : Impaired Processing is an Important Factor in Early Amyloidogenesis in Type 2 Diabetes

    Författare :Johan F. Paulsson; Gunilla Westermark; Christer Betsholtz; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biosynthesis amyloid; Genetics amyloid; Metabolism amyloid; Islets of Langerhans; Proprotein convertases; Posttranslation protein processing; Medical cell biology; Medicinsk cellbiologi;

    Sammanfattning : Amyloid is defined as extracellular protein aggregates with a characteristic fibrillar ultra-structure, Congo red affinity and a unique x-ray diffraction pattern. At present, 25 different human amyloid fibril proteins have been identified, and amyloid aggregation is associated with pathological manifestations such as Alzheimer’s disease, spongiform encephalopathy and type 2 diabetes. LÄS MER