Sökning: "SCN"

Visar resultat 1 - 5 av 30 avhandlingar innehållade ordet SCN.

  1. 1. Evolution of the Neuropeptide Y and Opioid Systems and their Genomic Regions

    Författare :Görel Sundström; Dan Larhammar; Manfred Schartl; Uppsala universitet; []
    Nyckelord :neuropeptide Y; opioid; evolution; genome duplication; gene duplication; Hox; SCN; IGFBP; MEDICINE; MEDICIN;

    Sammanfattning : Two whole genome duplications (2R) occurred early in vertebrate evolution. By using combined information from phylogenetic analyses and chromosomal location of genes, this thesis delineates the evolutionary history of two receptor-ligand systems that expanded by these large scale events. LÄS MER

  3. 2. Effects of aging and inflammatory molecules on the suprachiasmatic circadian clock

    Författare :Mikael Nygård; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Circadian; suprachiasmatic; synaptic; inflammation; cytokine; SOCS; interferon; tumor necrosis factor; neuron; firing;

    Sammanfattning : The suprachiasmatic nucleus (SCN) is considered the master circadian pacemaker in the mammalian brain and is vital for generating physiological and behavioral circadian rhythms. During aging and inflammatory conditions the circadian system is frequently affected, but relatively little is known about the mechanisms underlying such effects. LÄS MER

  4. 3. Design of Transition-Metal Nitride Thin Films for Thermoelectrics

    Författare :Sit Kerdsongpanya; Per Eklund; Björn Alling; Gunilla Wingqvist; Lars Hultman; Daniel Gall; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Thermoelectric devices are one of the promising energy harvesting technologies, because of their ability to convert heat (temperature gradient) to electricity by the Seebeck effect. Furthermore, thermoelectric devices can be used for cooling or heating by the inverse effect (Peltier effect). LÄS MER

  5. 4. Growth and Phase Stability Studies of Epitaxial Sc-Al-N and Ti-Al-N Thin Films

    Författare :Carina Höglund; Lars Hultman; Jens Birch; Daniel Gall; Linköpings universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP;

    Sammanfattning : ¨This Thesis treats the growth and characterization of ternary transition metal nitride thin films. The aim is to probe deep into the Ti-Al-N system and to explore novel Sc-Al-N compounds. Thin films were epitaxially grown by reactive dual magnetron sputtering from elemental targets onto single-crystal substrates. LÄS MER

  7. 5. Circadian rhythm dysfunction in the suprachiasmatic nucleus : effects of Trypanosoma brucei brucei infection and inflammatory cytokines

    Författare :Gabriella B Lundkvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Suprachiasmatic nucleus; slice; Trypanosoma brucei; sleeping sickness; spontaneous firing; rhytm; synaptic activity; GABA; glutamate; AMPA cytokines; sleep regulation; interferon-gamma; tumor necrosis factor-alpha;

    Sammanfattning : Alterations in the mammalian circadian pacemaker, the hypothalamic suprachiasmatic nuclei (SCN), were studied in an experimental rat model of African trypanosomiasis, or sleeping sickness, caused by infections with subspecies of Trypanosoma brucei (T b). Characteristic signs of the disease are marked disturbances in circadian rhythms, such as a fragmentation of the sleep-wake cycle. LÄS MER