Sökning: "S-adenosylmethionine decarboxylase"

Hittade 5 avhandlingar innehållade orden S-adenosylmethionine decarboxylase.

  1. 1. Polyamine Pathway as Drug Target against Malaria

    Författare :Janina Sprenger; Biogena aminer; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amino acid insertions; Crystallography; polyamine pathway; drug design; enzyme inhibition; ITC; ligand binding; malaria; Plasmodium falciparum; S-Adenosylmethionine decarboxylase; spermidine synthase.;

    Sammanfattning : Malaria, caused by the protozoan parasite Plasmodium falciparum is responsible for about 600.000 death cases every year. Mainly affected are populations of subtropical countries in Africa and the largest groups of victims are children below the age of 5 years. LÄS MER

  3. 2. A Study on Trypanosomal Polyamine Biosynthetic Enzymes

    Författare :Sima Nasizadeh; Biogena aminer; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cell cycle; protein turnover; trypanosomatids; polyamines; Ornithine decarboxylase; S-adenosylmethione decarboxylase; Parasitology human and animal ; Parasitologi människa och djur ;

    Sammanfattning : The polyamines, putrescine, spermidine, and spermine, are essential for all forms of life. The polyamine biosynthetic pathway has been shown to be a potential target for drugs against various trypanosomal parasitic diseases. LÄS MER

  4. 3. Effects of polyamine pool manipulation on genes expressed during the cell cycle

    Författare :Pia Berntsson; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Animal physiology; cyclin A; ODC; MCF-7; mitotic shake off; DENSPM; CHO; cDNA microarray; cell cycle; spermine; Djurfysiologi; AdoMetDC; 2D gel electrophoresis; polyamines; spermidine; putrescine;

    Sammanfattning : The polyamines - putrescine, spermidine and spermine - are polycations found within cells. They have been shown to be essential for optimal cell proliferation and cell survival. Cells maintain their polyamine levels in a well-regulated system involving biosynthesis, catabolism and uptake/excretion. LÄS MER

  5. 4. On the Role of Polyamines in Apoptosis

    Författare :Cecilia Hegardt; Bröstcancer-genetik; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; SSAT; DENSPM; spermine; polyamines; mitochondrial membrane potential; cytochrome c; caspase; flow cytometry; Jurkat cells; mouse thymocytes; thymus in vivo; programmed cell death; Dexamethasone-induced apoptosis; Fas-induced apoptosis; AdoMetDC; Cytology; oncology; cancerology; Cytologi; onkologi; cancer; Clinical biology; Klinisk biologi; Animal physiology; Djurfysiologi;

    Sammanfattning : Apoptosis is a kind of death that is best described as cellular suicide and it is important for normal tissue homeostasis. The process can be induced by a number of different stimuli and the dying cell goes through a defined pathway terminating in typical biochemical and morphological alterations of the cell. LÄS MER

  7. 5. Structural Studies of Polyamine Biosynthesis Enzymes: Potential Targets for Drugs against Tropical Parasites

    Författare :Veronica Tamu Dufe; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; inhibitors; protein crystallography; Molecular biophysics; Molekylär biofysik; tropical parasites; polyamine biosynthesis enzymes;

    Sammanfattning : Two enzymes involved in the biosynthesis of polyamines, ornithine decarboxylase (ODC, from human and Leishmania donovani) and spermidine synthase (SPDS, from Plasmodium falciparum and Caenorhabditis elegans) were studied using biochemical methods, homology modelling and X-ray crystallography. ODC catalyses the first and committed step in polyamine biosynthesis, the decarboxylation of ornithine to putrescine. LÄS MER