Sökning: "Recombinant immunogen"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Recombinant immunogen.

  1. 1. Production and delivery of recombinant subunit vaccines

    Författare :Christin Andersson; KTH; []
    Nyckelord :Affibody; Affinity chromatography; Affinity purification; DNA immunization; Expression plasmid; Fusion protein; Hydrophobic tag; Iscoms; Lipid tagging; Malaria; Mammalian cell expression; Recombinant immunogen; Respiratory Syncytial Virus; Semliki Fo;

    Sammanfattning : Recombinant strategies are today dominating in thedevelopment of modern subunit vaccines. This thesis describesstrategies for the production and recovery of protein subunitimmunogens, and how genetic design of the expression vectorscan be used to adapt the immunogens for incorporation intoadjuvant systems. LÄS MER

  3. 2. Autoantigenic properties of the U1-70K protein

    Författare :Elisabet Welin Henriksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :U1-70K protein; ribonucleoproteins; autoantigens; autoantibodies; epitopemapping; connective tissue disease; species specificity; cross reactions; amino acidsequence; recombinant proteins; mutagenesis;

    Sammanfattning : Patients with the autoimmune diseases systemic lupus erythematosus and mixed connective tissue disease produce autoantibodies directed towards specific groups of cellular constituents in their own body. Two of the targeted antigens are denoted Sm and RNP, and consist of distinct collections of splicing associated RNA-protein complexes. LÄS MER

  4. 3. Concepts in DNA immunization overcoming viral diversity and enhancing plasmid immunogenicity

    Författare :Erik Rollman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV; DNA-vaccine; gp 160; GM-CSF; HPV 16 L OBS I; MuLV; prime-boost;

    Sammanfattning : On April 23, 1984, the prominent scientist Robert Gallo held a historical press conference at the Department of Health and Human Services, Washington D.C., USA. He announced that his laboratory at the National Institutes of Health had over the last months isolated a retrovirus named Human T-cell Leukemia Virus type III (HTLV-III). LÄS MER

  5. 4. Giardiasis in Leon, Nicaragua : prevalence and protection

    Författare :Aleyda Téllez Sierra; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Giardia intestinalis is endemic in Nicaragua and affects children early in their lives. Infected individuals may be asymptomatic or suffer from acute or chronic diarrhea, malabsorption and weight loss. The prevalence of Giardia intestinalis infection in the population of León-Nicaragua was investigated. LÄS MER

  7. 5. Dissection of HIV-1 Env-specific B cell responses in non-human primates

    Författare :Christopher Sundling; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : It has been almost 30 years since the identification of HIV as the causative agent of AIDS. Despite considerable efforts to halt the spread of the virus, the epidemic continues in many parts of the world. The most efficient way to stop new infections is a prophylactic vaccine that blocks transmission at the viral portal of entry. LÄS MER