Sökning: "RNA load"
Visar resultat 1 - 5 av 60 avhandlingar innehållade orden RNA load.
1. Antiretroviral treatment of HIV-1 in Sweden with focus on virological aspects
Sammanfattning : From a clinical standpoint, there are many factors to consider when optimizing the care for people living with HIV (PLWH). With help from clinical guidelines, most obstacles can be addressed. Expanded knowledge is however in constant demand, from local conditions to universal processes. LÄS MER
2. Evaluation of reverse transcriptase assay for viral load monitoring
Sammanfattning : Retaining an active reverse transcriptase (RT) enzyme is a fundamental requirement for all retroviruses to replicate. Bearing in mind that HIV has a very high propensity to mutate measuring RT activity to determine the level of retroviral replication has the capacity to eliminate problems associated with divergence, as the virus at all costs must retain an active RT enzyme. LÄS MER
3. Regulation of Gene Expression in Multiple Myeloma Cells and Normal Fibroblasts : Integrative Bioinformatic and Experimental Approaches
Sammanfattning : The work presented in this thesis applies integrative genomic and experimental approaches to investigate mechanisms involved in regulation of gene expression in the context of disease and normal cell biology.In papers I and II, we have explored the role of epigenetic regulation of gene expression in multiple myeloma (MM). LÄS MER
4. Reverse Transcriptase Activity Assays for Retrovirus Quantitation and Characterization
Sammanfattning : Reverse transcriptase (RT) is a crucial enzyme for retrovirus replication, and its presence in the virion is indispensable for infectivity. This thesis illustrates the use of RT activity assays as tools for quantitation and characterization of different retroviruses, particularly HIV. LÄS MER
5. Cellular proteins binding to the HCV 5' and 3' UTRs
Sammanfattning : Hepatitis C virus (HCV) is a worldwide health problem with more than 170 million people infected by the virus. About 80% become chronic carriers, which may result in hepatocellular carcinoma. The lack of an in vitro cell culture system that allows propagation of the virus has hampered the development of a vaccine or anti-viral drugs against HCV. LÄS MER