Sökning: "RAD52"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet RAD52.

  1. 1. The maintenance of telomeres in the budding yeast Naumovozyma castellii

    Författare :Humberto Itriago; Molekylär cellbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Telomere; Telomere dynamics; Telomere-Binding Proteins; Cdc13; Rap1; RAD52; Rad51; Homologous recombination; ALT; Budding yeast; Naumovozyma castellii;

    Sammanfattning : Linear chromosomes of eukaryotic cells require the presence of functional nucleoprotein terminal structures, known as telomeres, to protect the integrity of the genome. The telomere is a highly dynamic and regulated structure constituted by short tandem DNA repeats rich in guanine nucleotides that extent as double-stranded DNA ending in a single-stranded 3′ overhang. LÄS MER

  3. 2. Characterization of Budding Yeast Nonhomologous End-Joining at DNA Double-Strand Breaks and Telomeres

    Författare :Sidney Carter; Stefan Åström; Ed Louis; Stockholms universitet; []
    Nyckelord :DNA repair; nonhomologous end-joining; double-strand break; Developmental Biology; miljömedicinsk utvecklingsbiologi;

    Sammanfattning : The yeast K. lactis efficiently integrates DNA by illegitimate recombination (IR). IR was completely dependent upon nonhomologous end-joining (NHEJ). In contrast to S. LÄS MER

  4. 3. The function of Smc5/6 in Drosophila development and at the heterochromatin-like locus HMR in budding yeast

    Författare :Martin Tran; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The structural maintenance of chromosome 5/6 (Smc5/6) complex is one out of many factors in the cell that maintain genome stability. Smc5/6 has been implicated in processes such as DNA double-strand break (DSB) repair, replication progression, and chromosome segregation. LÄS MER

  5. 4. Silencing and DNA double-strand break repair in budding yeast

    Författare :Andreas Kegel; Stefan Åström; Stephan Marcand; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Silencing; Reb1; DSB; NHEJ; Nej1; illegitimate recombination; yeast; Developmental biology; Utvecklingsbiologi;

    Sammanfattning : Transcriptional silencing that makes large chromosomal domains inaccessible for the transcriptional apparatus is nucleated at DNA elements called silencers. In K.lactis a 102bp HMLα silencer was defined revealing three distinct protein-binding regions (A, B, and C) that were required for silencing of HMLα. LÄS MER

  7. 5. Expression and regulation of Rad51 in human cells

    Författare :Jenny Flygare; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HsRad51 recombination; DNA repair; cell cycle; apoptosis; caspase-3; hybridization array;

    Sammanfattning : Double strand breaks (DSBs) can be caused by exogenous DNA damaging agents or by endogenous processes, and may lead to chromosomal breakage and rearrangement resulting in apoptosis or tumorigenesis. The repair of DSBs in higher eukaryotes is to a large extent accomplished by homologous recombination (HR), a process in which DNA from a complementary strand is used as a template for repair synthesis. LÄS MER