Sökning: "Polycomb repression"

Visar resultat 1 - 5 av 17 avhandlingar innehållade orden Polycomb repression.

  1. 1. Towards forecasting epigenetic repression

    Författare :Moa J. Lundkvist; Yuri B. Schwartz; Ludvig Lizana; Peter V. Kharchenko; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; epigenetics; Polycomb; PRC1; PRC2; H3K27 methylation; Monte-Carlo simulation; chromatin structure; Drosophila; molekylär bioteknik inst f molekylärbiologi ; molecular biotechnology dept of molecular biology ;

    Sammanfattning : Multicellular organisms form many different cell types from one genome, which requires differential gene activity. The Polycomb system upholds the correct gene expression programs by epigenetically silencing genes that encode critical transcription regulators. LÄS MER

  3. 2. Targeted Inhibition of Polycomb Repressive Complexes in Multiple Myeloma : Implications for Biology and Therapy

    Författare :Mohammad Alzrigat; Helena Jernberg-Wiklund; Fredrik Öberg; Kristina Drott; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Multiple Myeloma; Epigenetics; Polycomb; PRC2; PRC1; EZH2; BMI-1; UNC1999; PTC-209; Epigenetic Therapy; Medicinsk vetenskap; Medical Science; Molekylär medicin; Molecular Medicine;

    Sammanfattning : Multiple myeloma (MM) is a hematological malignancy of antibody producing plasmablasts/plasma cells. MM is characterized by extensive genetic and clonal heterogeneity, which have hampered the attempts to identify a common underlying mechanism for disease establishment and development of appropriate treatment regimes. LÄS MER

  4. 3. Methyltransferase Ash1, histone methylation and their impact on Polycomb repression

    Författare :Eshagh Dorafshan Esfahani; Yuri B. Schwartz; Jan Larsson; Dale Dorsett; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Trithorax Group proteins; Polycomb Group proteins; PRC1; PRC2; PRE; histone methylation; histone ubiquitylation; Ash1; SET domain; H3K36; H3K27; Drosophila;

    Sammanfattning : Antagonistic interactions between Polycomb Group (PcG) and Trithorax Group (TrxG) proteins orchestrate the expression of key developmental genes. Distinct maternally loaded repressors establish the silenced state of these genes in cells where they should not be expressed and later PcG proteins sense whether a target gene is inactive and maintain the repression throughout multiple cell divisions. LÄS MER

  5. 4. Expression and function of Suppressor of zeste 12 in Drosophila melanogaster

    Författare :Sa Chen; Åsa Rasmuson-Lestander; Jan Larsson; Mattias Mannervik; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Epigenetics; histone; polycomb; Drosophila; Suppressor of zeste 12; Genetics; Genetik; genetik; Genetics;

    Sammanfattning : The development of animals and plants needs a higher order of regulation of gene expression to maintain proper cell state. The mechanisms that control what, when and where a gene should (or should not) be expressed are essential for correct organism development. LÄS MER

  7. 5. The interplay of transcription and chromatin regulation during embryonic development

    Författare :George Hunt; Mattias Mannervik; Eileen Furlong; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; transcription; chromatin; chromatin-modifiers; p300 CBP; Polycomb repression; promoter proximal Pol II pausing; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : A fascinating aspect of multicellular development is the production of diverse cell types from an identical DNA genome, which depends on the ability to express different complements of genes across space and time. This thesis tries to address how the genome, within the chromatin structure that envelops it, is regulated to direct this complex process. LÄS MER