Sökning: "Ovarian cancer and Biomarkers"

Visar resultat 1 - 5 av 24 avhandlingar innehållade orden Ovarian cancer and Biomarkers.

1. 1. Hunting a Silent Killer. Biomolecular Approaches in Ovarian Cancer

   Författare :Nicolai Arildsen; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ovarian cancer; Molecular biology; genetic variant; TP53 mutation; early detection; Drug Screening Assays; Antitumor; bioinformatics; next generation sequencing; NGS; prognostic and predictive biomarkers; ovarian clear cell cancer; high-grade serous ovarian cancer;

   Sammanfattning : Ovarian cancer is a heterogeneous disease and recent advances in improving patient outcome havebeen limited. It is estimated that a woman’s risk of developing ovarian cancer during her lifetime is about 1 in 70, making it a frequently occurring cancer type in women. LÄS MER

3. 2. Immunohistochemical and molecular studies on ovarian cancer progression and prognosis

   Författare :Björn Nodin; Tumörmikromiljö; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epithelial ovarian cancer; prognostic and predictive biomarkers; tissue microarrays; androgen receptor; RBM3; Chek1; Chek2; MCM3; Dachshund 2; SATB1; KRAS mutation;

   Sammanfattning : Epithelial ovarian cancer (EOC) is the most lethal malignancy of the female reproductive tract. Due to vague symptomatology, the majority of EOC patients are diagnosed in advanced clinical stages with poor survival rates, despite improvements in surgical techniques and the advent of targeted therapeutics. LÄS MER

4. 3. Ovarian cancer. Biomarkers, surgical outcome and survival

   Författare :Pia Leandersson; Lund Obstetrik och gynekologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; epitelial äggstokscancer; biomarkörer; kirurgi; incidens; överlevnad; epithelial ovarian cancer; biomarkers; ovarian cancer surgery; incidence; survival;

   Sammanfattning : Ovarian cancer is the eighth most common female cancer worldwide and the most lethal of the gynaecologic malignancies. Around 700 women are diagnosed in Sweden per year. Due to vague symptoms most of the patients are diagnosed with late-stage epithelial ovarian cancer (EOC) and prognosis is poor, with a five-year survival of 49%. LÄS MER

5. 4. The role of RNA-binding motif 3 in epithelial ovarian cancer: A biomarker discovery approach

   Författare :Åsa Ehlén; Malmö Patologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA integrity checkpoint; cisplatin treatment; prognostic predictive marker; RBM3; epithelial ovarian cancer; Chk1; Chk2; MCM3;

   Sammanfattning : Epithelial ovarian cancer (EOC) is the most lethal of all gynaecological malignancies and there is an urgent need to develop new prognostic and treatment predictive biomarkers for a more efficient therapy. The discovery of the RNA-binding motif protein 3 (RBM3) as a putative cancer biomarker was based on its differential expression in various cancer forms in the Human Protein Atlas (HPA). LÄS MER

7. 5. Novel biomarkers associated with histotype and clinical outcome in early-stage ovarian carcinoma

   Författare :Hanna Engqvist; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ovarian carcinoma; histotype-specific diagnosis and prognosis; molecular biomarker; outcome prediction; integrative analysis;

   Sammanfattning : Ovarian cancer is a collective name for multiple malignancies deriving from or involving the ovary, mainly comprising five histotypes of epithelial origin (clear-cell (CCC), endometrioid (EC), high-grade serous (HGSC), low-grade serous (LGSC), and mucinous carcinomas (MC)) with varying clinical (e.g. LÄS MER