Sökning: "KRAS mutation"

Visar resultat 1 - 5 av 22 avhandlingar innehållade orden KRAS mutation.

  1. 1. Molecular Genetic Alterations In Endometrial And Ovarian Cancers

    Författare :Anjila Koul; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; KRAS; PTEN; TP53; Overexpression; Mutation; Microsatellite instability; Complex atypical hyperplasia; Endometrial cancer; Ovarian cancer; cancer; onkologi; Cytologi; cancerology; oncology; Cytology; CNS metastasis; Cytogenetic analysis; BRCA2; BRCA1; B-catenin; CDKN2A;

    Sammanfattning : Endometrial cancer is the most common gynecological cancer diagnosed in western countries. Complex atypical hyperplasia (CAH) reflects a state of hyperestrinism and its role as a precursor lesion of this cancer is established. LÄS MER

  3. 2. Mutation and immune profiling of non-small cell lung cancer

    Författare :Linnéa La Fleur; Johan Botling; Fernando López-Ríos; Uppsala universitet; []
    Nyckelord :Non-small cell lung cancer; Tumor microenvironment; Tumor-associated macrophages; Immune infiltrates; PD-L1; Mutation patterns; Immune therapy; MARCO; TP53; STK11; KRAS;

    Sammanfattning : Several novel therapies that target molecular alterations and immune checkpoints in lung cancer have been introduced in the last decade. Still, only a minority of patients obtain long term disease control and overall survival remains poor. LÄS MER

  4. 3. Molecular understanding of KRAS- and BRAF-mutated colorectal cancers

    Författare :Ida Lundberg; Richard Palmqvist; Maria Wikberg; Sofia Edin; Anita Sjölander; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal cancer; BRAF; KRAS; SOX2; CDX2; cancer stem cell; Th1 lymphocytes; miRNA; prognosis;

    Sammanfattning : Colorectal cancer (CRC) is the third most commonly diagnosed malignancy in both men and women, and one of the leading causes of cancer-related deaths worldwide. One frequently mutated pathway involved in oncogenesis in CRC is the RAS/RAF/MAP kinase pathway. LÄS MER

  5. 4. A cohort study of sex differences and prognostic biomarkers in colorectal cancer

    Författare :Sakarias Wangefjord; Tumörmikromiljö; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal cancer; prognosis; treatment prediction; biomarkers; sex differences; cyclin D1; microsatellite instability; beta-catenin; KRAS mutation; BRAF mutation; EGFR expression; EGFR gene copy number alterations;

    Sammanfattning : Colorectal cancer (CRC) is one of the most common forms of cancer worldwide, with an annual incidence of more than 1 million cases. Despite advancements in the management of CRC, mortality remains high. LÄS MER

  7. 5. Associations of sex, anthropometric and reproductive factors with clinicopathological and molecular characteristics of colorectal cancer

    Författare :Jenny Brändstedt; Tumörmikromiljö; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal cancer; carcinogenesis; MDCS; anthropometrics; risk factors; sex differences; hormonal therapy; beta-catenin; cyclin D1; p53; MSI; KRAS mutation; BRAF mutation;

    Sammanfattning : Colorectal cancer (CRC) is the third most common cancer globally, with approximately 1.2 million new cases every year. The highest incidence rates are seen in developed countries, thereby imposing dietary and lifestyle factors in the etiology of CRC. LÄS MER