Sökning: "Encapsulated cell biodelivery"

Hittade 4 avhandlingar innehållade orden Encapsulated cell biodelivery.

  1. 1. Advancing gene therapy for epilepsy. Translational pre-clinical studies with neuropeptide Y and glial cell-line derived neurotrophic factor

    Författare :Esbjörn Melin; Epilepsicentrum; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epilepsy; Gene Therapy; neuropeptide Y NPY ; Y2 receptor; GDNF; Encapsulated cell biodelivery; seizure; In-vivo;

    Sammanfattning : Epilepsy is a neurological disorder, affecting approximately 1% of the population. The high rate of drug-resistance in epilepsy in general (30%), and temporal lobe epilepsy (TLE) in particular, pose a serious clinical problem. Thus, novel treatments for drug-resistant epilepsy is highly warranted. LÄS MER

  3. 2. Neuropeptides and neurotrophic factors in epilepsy: seizure suppressant actions of VEGF, NPY and galanin

    Författare :Litsa Nikitidou; Lund Neurologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epilepsy; Gene Therapy; Neuropeptide Y; Y2 receptor; Y5 receptor; Galanin; Encapsulated cell biodelivery; Vascular endothelial growth factor; Flk-1; Hippocampus;

    Sammanfattning : Epilepsy is a severe chronic neurological disorder, affecting about 1% of the population. The disease is manifested by spontaneous recurrent seizures, caused by hypersynchronized neuronal activity due to imbalance in the brain between the inhibition and excitation. LÄS MER

  4. 3. Nerve growth factor in Alzheimer’s disease : biological effects and therapeutic potential

    Författare :Helga Eyjolfsdottir; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer’s disease (AD) is a progressive neurodegenerative disorder against which there is yet no disease modifying or curative treatment. Degeneration of cholinergic basal forebrain (CBF) neurons plays a role in the pathogenesis of AD and these neurons are highly dependent on nerve growth factor (NGF) for growth and survival. LÄS MER

  5. 4. Bridging the gap between lipid dyshomeostasis and brain disorders : role of prosaposin and progranulin

    Författare :Yachao He; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Brain tissue is the second-highest lipid-containing tissue after adipose in the human body. Lipid homeostasis maintenance requires the coordination of multiple cellular organelles. Pathogenesis of brain disorders, especially Parkinson’s disease (PD), usually involves different dysfunctional pathways that intimately link to lipid homeostasis. LÄS MER