Sökning: "NK-92 cells"

Hittade 3 avhandlingar innehållade orden NK-92 cells.

1. 1. Genetic modification of human natural killer cells and possible applications thereof

   Författare :Kyriakos Konstantinidis; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Natural killer cells; retroviral transduction; interleukin-2; endoplasmic reticulum targeting; green fluorescent protein; multiple myeloma;

   Sammanfattning : Natural killer (NK) cells are dependent on the presence of interleukin-2 (IL-2) for their survival and for their cytotoxicity against tumor cells. Currently, for in vitro expansion of NK cells from peripheral blood mononuclear cells (PBMCs), IL-2 is of great importance. LÄS MER

3. 2. Natural killer cells, multiple myeloma, and daratumumab : a love-hate relationship

   Författare :Michael Chrobok; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Multiple myeloma is a treatable, but not yet curable, malignant plasma cell disease. Over the last decades, the overall survival time of multiple myeloma patients has constantly increased thanks to improvements in conventional treatment methods like chemotherapy as well as autologous stem cell transplantation both in combination with novel drugs such as proteasome inhibitors or immunomodulatory drugs. LÄS MER

4. 3. Migration of Natural Killer Cells. Matrix interaction, locomotion and regulation of matrix metalloproteinases (MMPs) by IL-2 and chemokines

   Författare :Karin Edsparr; Göteborgs universitet; []
   Nyckelord :NK cell; MMP; Matrigel; migration; IL-2;

   Sammanfattning : Activated natural killer (NK) cells are effective anti-tumour cells. In order to reach target cells in a tumour mass they need to migrate in the extravascular space. LÄS MER