Sökning: "endoplasmic reticulum targeting"

Visar resultat 1 - 5 av 27 avhandlingar innehållade orden endoplasmic reticulum targeting.

  1. 1. Insulin secretion and ASNA-1-dependent function of the endoplasmic reticulum in C. elegans

    Författare :Ola Billing; Gautam Kao; Jussi Jäntti; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cell research; cellforskning; genetik; Genetics;

    Sammanfattning : ASNA1 is a well-conserved ATPase involved in a wide range of functions, including cisplatin resistance, growth control, insulin secretion and targeting of tail-anchored (TA) proteins to membranes. It is a positive regulator of insulin secretion both in the roundworm Caenorhabditis elegans and in humans. LÄS MER

  3. 2. Characterization of p58 and rab1p, two proteins operating at the interface of the endoplasmic reticulum and the Golgi complex

    Författare :Ulla Lahtinen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :protein transport; rab1p; p58; animal lectin; intermediate compartment; endoplasmic reticulum; Golgi complex;

    Sammanfattning : Endomembranes participating in the early stages in exocytosis consist of the endoplasmic reticulum (ER), the Golgi complex, and vesicular transport intermediates at their interface. These vesicular transport intermediates were first visualized by following the synchronized transport of a viral membrane protein from the ER to the Golgi complex, which occurs at slower rates at reduced temperatures causing an accumulation of transport vesicles. LÄS MER

  4. 3. NA transmembrane domain : Amphiphilic drift to accommodate two functions

    Författare :Johan Nordholm; Robert Daniels; Ervin Fodor; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; influenza; IAV; neuraminidase; NA; transmembrane domain; TMD; secretory protein; ER-targeting sequence; ER-targeting sequence coding region; protein regulation; NS1; GALLEX; Biochemistry; biokemi;

    Sammanfattning : Neuraminidase (NA) is one of two major antigens on the surface of influenza A viruses. It is comprised of a single N-terminal transmembrane domain (TMD), a stalk domain, and a C-terminal enzymatic head domain that cleaves sialic acid, most notably to release new particles from the host cell surface. LÄS MER

  5. 4. Targeted disruption and subcellular distribution of phospholipase C 3

    Författare :Shu Wang; Uppsala universitet; []
    Nyckelord :Medical sciences; Phosphoinositide specific phospholipase C; sequencing; fluorescence in situ hybridization; gene targeting; earlyembryonic development; electron microscopy; secretory granules; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Internal Medicine; invärtesmedicin;

    Sammanfattning : Phosphatidylinositol specific phospholipase C (PLC) isoforms are key enzymes in the signal transduction pathway that control many cellular processes including cell proliferation, hormone secretion and egg fertilization. The PLCβ3 gene, assigned to the multiple endocrine neoplasia type 1 (MEN1) locus, has been implicated in endocrine tumorigenesis due to the low expression in several endocrine tumors. LÄS MER

  7. 5. Genetic modification of human natural killer cells and possible applications thereof

    Författare :Kyriakos Konstantinidis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Natural killer cells; retroviral transduction; interleukin-2; endoplasmic reticulum targeting; green fluorescent protein; multiple myeloma;

    Sammanfattning : Natural killer (NK) cells are dependent on the presence of interleukin-2 (IL-2) for their survival and for their cytotoxicity against tumor cells. Currently, for in vitro expansion of NK cells from peripheral blood mononuclear cells (PBMCs), IL-2 is of great importance. LÄS MER