Sökning: "Morphine tolerance"

Visar resultat 1 - 5 av 16 avhandlingar innehållade orden Morphine tolerance.

  1. 1. Mechanisms of opiate tolerance and dependence in the rat

    Författare :Orsolya Hoffman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Drug addiction is a complex phenomenon with various biological, psychological and social causes and consequences, which belongs to the major problems of today's society. Opiates have been used and misused for thousand of years and addiction to them develops both in humans and in animals. LÄS MER

  3. 2. Characterization of the antinociceptive effects of morphine and its glucuronides : Pharmacokinetic-pharmacodynamic modeling

    Författare :Marie Gårdmark; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; Biopharmaceutics; biofarmaci;

    Sammanfattning : Pharmacodynamic modeling was used to quantify the time aspects of theantinociceptive effect in rats following administration of morphine, morphine-3-glucuronide (M3G) and morphine-glucuronide (M6G). M6G acts as a potentagonist of morphine actions, whereas the pharmacodynamic role of M3G has beenunclear. LÄS MER

  4. 3. The Impact of Substance P (SP) N-Terminal Metabolite SP1-7 in Opioid Tolerance and Withdrawal

    Författare :Qin Zhou; Tsukasa Sakurada; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; farmaceutisk biokemi; Pharmaceutical Biochemistry;

    Sammanfattning : The heptapeptide SP1-7, a metabolite of the neuroactive peptide substance P (SP), is suggested to play a role in opioid addiction and memory function. These two dimensions are known to involve dopamine and glutamate transmissions mediated through dopamine receptors and N-methyl-D- aspartate (NNMA) receptors, respectively. LÄS MER

  5. 4. The analgesic mechanisms of buprenorphine

    Författare :Poli Francois Kouya; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Buprenorphine; morphine; cross-tolerance; g- opioid receptors; inbred mice.;

    Sammanfattning : Buprenorphine, a derivative of thebaine, is a semi-synthetic opiate and a partial p-opioid receptor agonist. Buprenorphine is also a weak kappa-opioid receptor antagonist. Buprenorphine is used clinically as an analgesic and for maintenance therapy of opiate-dependent subjects because it produces limited withdrawal symptoms. LÄS MER

  7. 5. On cholecystokinin-opioid interaction in the spinal dorsal horn following peripheral nerve injury and inflammation

    Författare :Guilherme de Araújo Lucas; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cholecystokinin; Cholecystokinin receptors; Morphine; Spinal cord; Axotomy; Inflammation; Peptide release; Morphine tolerance; [my]-opioid receptor; Flexor reflex; Microdialysis;

    Sammanfattning : The peptide cholecystokinin (CCK) antagonizes opioid-induced analgesia. Conversely, antagonists of CCK receptors enhance the analgesic effect of opioids. Together, these results support a role for CCK as an anti-opioid peptide in pain mechanisms. LÄS MER