Sökning: "Axotomy"

Visar resultat 1 - 5 av 40 avhandlingar innehållade ordet Axotomy.

1. 1. Transcriptional regulation of the neuropeptide galanin : special reference to axotomy

   Författare :Jacqueline D Corness; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :galanin; axotomy; nerve injury; neuropeptide; leukaemia inhibiting factor; transcription; dorsal root ganglion; nerve growth factor;

   Sammanfattning : Galanin is a neuropeptide which is located in both the central and peripheral nervous system. In peripheral neurones, this peptide is thought to be involved in influencing pain sensation after nerve injury (neuropathic pain) and also in the regeneration of peripheral nerves. LÄS MER

3. 2. Autoimmune and innate inflammation in the nervous system : neurotrophin production and impact on neuronal survival

   Författare :Cecilia Lundberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :neurodegeneration; autoimmunity; neurotrophin; motoneuron; cytokine; axotomy;

   Sammanfattning : The occurrence of a continuous immune surveillance in the central nervous system (CNS) is a fairly recent finding. For long the CNS was considered an immune privileged organ, with the blood-brain barrier constituting an effective barrier against blood-derived molecules and cells. LÄS MER

4. 3. Genetics and inflammation in nerve injury-induced neurodegeneration

   Författare :Olle Lidman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Axotomy; Motoneuron; Neurodegeneration; Immunity; Microglia; MHC; QTL Mapping.;

   Sammanfattning : Neurodegeneration and inflammation are characteristic of many diseases of the central nervous system (CNS) and understanding the molecular networks that regulate these processes is of central importance for the development of effective therapies. Although the CNS has traditionally been regarded as an immuno privileged organ, immune reactions, including components of both local innate and systemic immunity, do occur in this tissue. LÄS MER

5. 4. Neuropeptide release in the rat dorsal horn in models of persistent pain : effects of opioids

   Författare :Abdullahi Warsame Afrah; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Axotomy; Inflammation; Long term potentiation; Capsaicin; Opioids; Cholecystokinin; Substance P; Glutamate; NMDA; Spinal cord; Microdialysis; Radioimmunoassay.;

   Sammanfattning : Nerve injury and tissue inflammation may lead to exaggerated responses to both noxious stimuli (hyperalgesia) and innocuous stimuli (allodynia). Altered release pattems of neurotransmitters in the dorsal hom of the spinal cord have been suggested to contribute to hyperalgesia and allodynia. LÄS MER

7. 5. Spinal motoneurons and molecules related to neurotrophic function after axon injury

   Författare :Henrik Hammarberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :immunohistochemistry; in situ hybridization; spinal cord; motoneuron; axotomy; survival; regeneration; MHC 1; leukocyte; cell culture; mRNA expression;

   Sammanfattning : The capacity of motoneurons to survive and regenerate new axons after injuries such as axotomy depends on a great variety of parameters. After sciatic nerve transection (SNT) in adult rats and to some extent after a ventral funiculus lesion (VFL), many cells survive and regeneration is highly prioritized. LÄS MER