Sökning: "Malin Celander"
Hittade 3 avhandlingar innehållade orden Malin Celander.
1. Experimental Studies of Endocrine Disrupting Compounds in Vascular Cells and Tissues
Sammanfattning : Epidemiological evidence suggest that exposure to endocrine disrupting compounds (EDCs) is a risk factor for diseases that involves the cardiovascular system but we know little about the mechanisms whereby these compounds can cause injury in the vasculature. The aim of this thesis was to characterize the effects and mechanisms of some EDCs in vascular cells and highly vascularized tissues. LÄS MER
2. The impact of cytochrome P4501-inhibitors on aryl hydrocarbon receptor signaling
Sammanfattning : The aryl hydrocarbon receptor (AHR) best known as a ligand-activated transcription factor that mediates toxic responses to xenobiotics such as dioxins, is also activated by certain endogenous compounds. Activation of the AHR up-regulates transcription of a large number of genes, including those encoding members of the cytochrome P450 1 family of enzymes (CYP1s). LÄS MER
3. Molecular and phenotypical toxicological effects of environmental pollutants and their mixtures : A mechanistic approach
Sammanfattning : Current environmental risk assessment of polluted sites primarily relies on single compound evaluation. However, in the environment, organisms are often exposed to complex mixtures of pollutants. LÄS MER