Sökning: "Lipid droplets"

Visar resultat 1 - 5 av 39 avhandlingar innehållade orden Lipid droplets.

1. 1. The assembly of cytosolic lipid droplets and its effect on insulin sensitivity

   Författare :Pontus Boström; Göteborgs universitet; []
   Nyckelord :diabetes; lipid metabolism; insulin resistance; lipid droplets; ADFP; SNARE;

   Sammanfattning : Accumulation of neutral lipids, in particular triglycerides, in non-adipocytes is highly related to the development of insulin resistance and its consequences, type-2 diabetes and cardiovascular diseases. The accumulation of triglycerides occurs in so-called lipid droplets in the cytosol. LÄS MER

3. 2. Cardiac lipid storage and metabolism following myocardial ischemia

   Författare :Christina Drevinge; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lipid accumulation; Myocardial Ischemia; Lipid droplets; Perilipin2; Perilipin5;

   Sammanfattning : Myocardial ischemia is associated with cellular- and metabolic adjustments within the heart, including accumulation of lipids. Myocardial lipids are stored in cytosolic droplets, consisting of a core of neutral lipids surrounded by a complex surface containing proteins, such as perilipins. LÄS MER

4. 3. Studies on the assembly of cytosolic lipid droplets. Importance of Phospholipase D and ADRP in the process

   Författare :Denis Marchesan; Göteborgs universitet; []
   Nyckelord :Lipid droplets; triglycerides; caveolin; Phospholipase D PLD ; adipocyte differentiation related protein ADRP ; EGCG;

   Sammanfattning : The storage of triglycerides in cells such as adipocytes, liver or muscle cells is of great physiological importance, having implications for our most important metabolic diseases such as obesity, the metabolic syndrome and type II diabetes. A common denominator in these diseases is the insulin resistance, which is also highly related to the production of atherogenic lipoproteins and the development of atherosclerosis and consequently cardio-vascular diseases. LÄS MER

5. 4. Cardiac lipids and their role in the diseased heart

   Författare :Ismena Mardani; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiovascular disease; Lipid droplets; Perilipins; Lipid accumulation; Metabolism; GlcCer;

   Sammanfattning : Lipids play an essential role within the heart as they are involved in energy storage, membrane stability and signaling. Changes in cardiac lipid composition and utilization may thus have profound effects on cardiac function. Importantly, the diseased heart is associated with intracellular metabolic abnormalities, including accumulation of lipids. LÄS MER

7. 5. Astrocytes in Alzheimer’s disease : Exploring the impact of amyloid-β pathology on neurotoxicity, metabolism and inflammation

   Författare :Chiara Beretta; Anna Erlandsson; Dag Sehlin; Christian Tackenberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; astrocytes; amyloid-beta; extracellular vesicles; mitochondria; lipid droplets; lipid metabolism; inflammation; Molekylär medicin; Molecular Medicine;

   Sammanfattning : Astrocytes play a central role in brain homeostasis, but are also tightly connected to the pathogenesis of Alzheimer’s disease (AD). Yet, their exact role in amyloid-beta (Aβ) pathology and chronic neuroinflammation is unclear. The aim of this thesis was to elucidate the impact of astrocytes in AD progression. LÄS MER