Avancerad sökning

Visar resultat 1 - 5 av 206 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Genetic Determinants of Dyslipidemia

   Författare :Tibor V Varga; Genetisk och molekylär epidemiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetic epidemiology; Genetic polymorphism; dyslipidaemia; Cholesterol; Triglyceride; Genetic risk; genetic risk score; Single nucleotide polymorphism; Prediction; Gene-environment interactions; Randomized controlled trial; prospective cohort studies; Observational study; GLACIER Study; Diabetes Prevention Program;

   Sammanfattning : Dyslipidemia is a chronic deviation from normal blood lipid levels that can lead to atherosclerosis and other cardiovascular diseases; dyslipidemia and its sequelae are caused by the complex interplay of genetic and environmental factors. Although circulating concentrations of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (LDL-C) have a strong genetic underpinning, not much is known about the genetic factors that affect long-term deteriorations in lipid concentrations. LÄS MER

3. 2. Genetic epidemiology of prostate cancer

   Författare :Fredrik Wiklund; Henrik Grönberg; Douglas Easton; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; prostate cancer; epidemiology; genetics; linkage analysis; genome-wide scan; Onkologi; Oncology; Onkologi; Oncology; onkologi;

   Sammanfattning : Prostate cancer is a major health burden throughout the world, yet the etiology of prostate cancer is poorly understood. Evidence has accumulated supporting the existence of a hereditary form of this disease. LÄS MER

4. 3. Molecular Epidemiology of Cardiovascular Disease

   Författare :Markus Stenemo; Johan Ärnlöv; Rikard Landberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomarkers; ischemic stroke; heart failure; omics; proteomics; metabolomics; epidemiology; risk marker; Epidemiologi; Epidemiology;

   Sammanfattning : Cardiovascular disease is a major cause of morbidity and mortality, with increasing prevalence worldwide.Identification of risk markers may enable improved prevention by targeting high-risk individuals, earlier disease diagnosis and treatment, as well as stratification of disease subtypes with different treatment options, thereby minimizing side effects while increasing success rates. LÄS MER

5. 4. Genetic genealogy and epidemiology of Francisella

   Författare :Kerstin Svensson; Anders Johansson; Mats Forsman; Sam R. Telford III; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Francisella tularensis; tularemia; genotyping; epidemiology; GIS; Infectious diseases; Infektionssjukdomar; Infectious Diseases; infektionssjukdomar;

   Sammanfattning : This thesis is about analyzing genetic differences among isolates of Francisella tularensis – the tularemia-causing bacterium. To elucidate how these bacterial isolates are related, and their geographical and genetic origins, I have developed typing assays for Francisella and used them to study the epidemiology of tularemia. LÄS MER

7. 5. INDIVIDUAL GENETIC RESEARCH RESULTS : Uncertainties, Conceptions, and Preferences

   Författare :Jennifer Viberg Johansson; M G Hansson; Pär Segerdahl; Sophie Langenskiöld; Marion McAllister; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Incidental findings; genetic risk information; research participants; risk perception; free choice; framing; conceptions of genetic risk; making sense of genetic risk; preferences for genetic risk information;

   Sammanfattning : This thesis contributes to the ethical discussion on how to handle incidental findings in biomedical research using sequencing technologies from a theoretical and an empirical perspective. Study I and II are theoretical studies that used conceptual analysis. LÄS MER